UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

ABI1 — ARPC4

Pathways - manually collected, often from reviews:

NCI Pathway Database PDGFR-beta signaling pathway: WAVE2/Nap1/Sra1/ABI1/HSPC300 complex (WASF2-NCKAP1-CYFIP2-ABI1-BRK1) → Arp2/3 complex complex (ACTR2-ACTR3-ARPC1B-ARPC2-ARPC3-ARPC4-ARPC5) (modification, activates)
Innocenti et al., Nat Cell Biol 2004, Leng et al., Proc Natl Acad Sci U S A 2005
Evidence: mutant phenotype, assay
NCI Pathway Database ErbB1 downstream signaling: ABI1/N-WASP complex (ABI1-WASL) → Arp2/3 complex complex (ACTR2-ACTR3-ARPC1B-ARPC2-ARPC3-ARPC4-ARPC5) (modification, activates)
Kurokawa et al., Mol Biol Cell 2004, Innocenti et al., Nat Cell Biol 2005
Evidence: mutant phenotype
NCI Pathway Database RAC1 signaling pathway: WAVE2/Nap1/Sra1/ABI1/HSPC300 complex (WASF2-NCKAP1-CYFIP2-ABI1-BRK1) → Arp2/3 complex complex (ACTR2-ACTR3-ARPC1B-ARPC2-ARPC3-ARPC4-ARPC5) (modification, activates)
Yamazaki et al., J Cell Sci 2007, Bosse et al., Mol Cell Biol 2007, Ryu et al., Mol Cell Biol 2009
Evidence: assay, physical interaction
NCI Pathway Database ErbB1 downstream signaling: WAVE2/Nap1/Sra1/ABI1/HSPC300 complex (WASF2-NCKAP1-CYFIP2-ABI1-BRK1) → Arp2/3 complex complex (ACTR2-ACTR3-ARPC1B-ARPC2-ARPC3-ARPC4-ARPC5) (modification, activates)
Innocenti et al., Nat Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction
Reactome Reaction: ARPC4 → ABI1 (indirect_complex) Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001
Reactome Reaction: ARPC4 → ABI1 (reaction) Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001, Le Clainche et al., Proc Natl Acad Sci U S A 2003, Kovar et al., Nat Cell Biol 2006

Text-mined interactions from Literome

Suetsugu et al., J Cell Biol 2006 : WAVE2 activates the actin related protein (Arp) 2/3 complex for Rac induced actin polymerization during lamellipodium formation and exists as a large WAVE2 protein complex with Sra1/PIR121, Nap1, Abi1, and HSPC300
Nakanishi et al., J Biochem 2007 : Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex