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CASP6 — PCNA

Text-mined interactions from Literome

Harvey et al., J Cell Biol 2000 : The caspase dependent activation of cyclin dependent kinases (Cdks) in varied cell types in response to disparate suicidal stimuli has prompted our examination of the role of Cdks in cell death
Mazumder et al., Mol Cell Biol 2002 : The p18-cyclin E expression was prevented by Bcl-2 overexpression and by the general caspase and specific caspase 3 pharmacologic inhibitors zVAD-fluoromethyl ketone ( zVAD-fmk ) and N-acetyl-Asp-Glu-Val-Asp-aldehyde ( DEVD-CHO ), indicating that it was linked to apoptosis
Lukovic et al., Exp Cell Res 2003 : We found previously that caspase dependent nuclear cyclin dependent kinase 2 (Cdk2) activity appears to be necessary for cell death
Ghatnekar et al., Birth Defects Res A Clin Mol Teratol 2004 (Hypoglycemia) : Protein expression of caspase-3 active subunit and p53 was increased and PCNA was markedly reduced in hearts of embryos exposed to hypoglycemia
Faraglia et al., J Cell Physiol 2005 (Breast Neoplasms) : Cyclin D1 expression level was not affected by caspase-3 expression
Lau et al., Cancer Biol Ther 2007 (Carcinoma, Hepatocellular...) : In the in vivo setting, YC-1 combined with cisplatin remarkably suppressed tumor growth in a HCC xenograft model, and this effect was also accompanied by YC-1 mediated downregulation of P-Stat3 ( 705 ), Bcl-xL, Cyclin D1 and survivin, and induction of cleaved caspase 9 and PARP in the tumor tissues
Long et al., Transplant Proc 2008 : The intragraft expression of TNF-alpha and caspase-3 was strikingly promoted in the normal saline treated group and PCNA attenuated compared to the ALR group
Giri et al., Anticancer Res 2009 (Colonic Neoplasms) : Curcumin together with BM-ANF1 produced a greater inhibition of HCT-116 cells growth than either agent alone, attributable to the inhibition of proliferation and stimulation of apoptosis, as evidenced by suppression of proliferating cell nuclear antigen ( PCNA ) expression, cell cycle arrest at the G2/M-phase and caspase-3 activation
Wang et al., J Asian Nat Prod Res 2009 : 1 in high concentrations induced Bax, caspase-3 , and cyclin dependent kinase (CDK) inhibitor P21 expression, whereas the expressions of cyclin CDK2, Bcl-2, and proliferating cell nuclear antigen ( PCNA ) were decreased by 1 treatment
Long et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010 (Liver Neoplasms, Experimental) : TUNEL showed that DADS enhanced the cell apoptosis and apoptosis promoting protein caspase-3 expression, decreased apoptosis inhibiting protein bcl-2 expression, and also inhibited proliferation associated protein PCNA expression
Yang et al., Mol Med Report 2010 : The expression of cyclin D1 , cyclin dependent kinase 4 (CDK4), Bcl-2, Bcl-xL and the activation of caspase-3 were examined by Western blotting
Wang et al., J Cancer Res Clin Oncol 2012 (Carcinoma...) : The mechanism is at least partially due to the inhibition of NF-?B activity and consequent inhibition of c-Myc, COX-2, Cyclin D1, Survivin, Bcl-2 and Bcl-xL, and the activation of caspase-3
Zhang et al., PloS one 2012 : It is possible that the elevated cAMP levels inhibit growth and induce apoptosis in Hela cells through induction of p21 and cleaved caspase-3/PARP-1 expression, and causing down-regulation of PCNA and cell cycle arrest with accumulation of cells in the G0/G1 and G2/M fractions
Ma et al., Archives of medical science : AMS 2013 : Meanwhile, EsA reduced the serum IL-6 and TNF-a levels ( p < 0.05 ), inhibited the expression of PCNA and promoted the expression of caspase-3 , Fas and FasL in animals of the treated group ( p < 0.05 )