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Cho et al., Brain Res 2008
:
These findings are consistent with the idea that activation of TRPV1 in peripheral axons of joint afferents may mediate the synovial release of neuropeptides in arthritis
Jara-Oseguera et al., Curr Mol Pharmacol 2008
(Pain) :
TRPV1 activation in nociceptive neurons, where it is normally expressed, triggers the release of neuropeptides and transmitters resulting in the generation of action potentials that will be sent to higher CNS areas where they will often be perceived as pain
Keszthelyi et al., Eur J Pain 2013
:
Activation of TRPV1 leads to the release of neuropeptides , such as somatostatin and substance P ( SP )
Paltser et al., Mol Med 2013
:
The TRPV1 ( + ) neurovascular complex defining the blood-CNS barriers promoted invasion of pathogenic lymphocytes without the contribution of TRPV1 dependent neuropeptides such as substance P