Shepherd et al., Leukemia 2013
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
Pajvani et al., Nat Med 2013
(Body Weight...) :
We demonstrate that Notch signaling increases mTorc1 complex stability, augmenting mTorc1 function and sterol regulatory element binding transcription factor 1c ( Srebp1c ) -mediated lipogenesis