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MAPK13 — SMAD3

Text-mined interactions from Literome

Wrana et al., Science's STKE : signal transduction knowledge environment 2000 : In the cytosol, Smad translocation might be inhibited by mitogen activated protein kinase dependent phosphorylation, whereas in the nucleus Smads interact with a number of transcription factors that themselves are primary targets of other signaling pathways
Furukawa et al., Hepatology 2003 (Liver Cirrhosis) : In conclusion, p38 MAPK dependent Smad3 phosphorylation promoted extracellular matrix production in MFBs both in vitro and in vivo
Galliher et al., Cancer Res 2007 (MAP Kinase Signaling System...) : Interestingly, although the expression of Y284F-TbetaR-II mutants in breast cancer cells had no effect on TGF-beta stimulation of Smad2/3 , this TbetaR-II mutant completely abrogated p38 MAPK activation by TGF-beta
Daniel et al., J Cell Biochem 2007 : Using a specific inhibitor, we were also able to demonstrate an involvement of the p38 MAPK in the increase of Smad 3 phosphorylation following butyrate treatment, thus opening the view to further elucidate possible mechanisms mediating the upregulation of VDR expression following butyrate treatment in colon cancer cells
Zhao et al., Mol Cell Biochem 2008 (Fibrosis...) : Additionally, the inhibition of MAPK signaling had no effect on Smad activation elicited by chymase
Zhu et al., Prostate 2010 (MAP Kinase Signaling System) : These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF-beta via Smad dependent pathway ( apoptosis ) and MAPK intracellular signaling ( survival )
Rodrigues Díez et al., PloS one 2010 (Fibrosis) : In cultured rat VSMCs, direct AngII/Smad pathway activation was mediated by p38 MAPK and ROCK activation
Ungefroren et al., Int J Oncol 2011 (Carcinoma, Pancreatic Ductal...) : Biochemically, dnSrc inhibition failed to block TGF-ß1/ALK5 induced activation of Smad2 and Smad3, but partially inhibited transcriptional activation of TGF-ß/Smad-responsive reporter genes, and effectively blocked basal and TGF-ß1 induced activation of p38 MAPK
Suwanabol et al., J Vasc Surg 2012 : Overexpression of the signaling protein Smad3 enhanced TGF-ß induced activation of ERK MAPK , whereas inhibition of Smad3 with a siRNA blocked ERK MAPK phosphorylation in response to TGF-ß ... Immunoprecipitation of phospho-ERK MAPK and blotting with Smad3 revealed a physical association, suggesting that activation of ERK MAPK by Smad3 requires a direct interaction ... In an in vivo rat carotid injury model, overexpression of Smad3 resulted in an increase in phosphorylated ERK MAPK as well as increased VSMC proliferation as measured by proliferating cell nuclear antigen
Fang et al., J Biol Chem 2012 (Breast Neoplasms...) : Disruption of Smad3 expression in mammary carcinoma cells blocked CCL2 induced cell survival and migration and partially reduced p42/44MAPK phosphorylation
Xu et al., Int J Oncol 2013 : p38 MAPK inhibitors ( SB 203580 ) can attenuate TGF-ß1 induced Smad3 expression and suppress the activation of smad3