Lawson et al., Eur J Immunol 2010
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In double positive cells, Egr2 is upregulated immediately following TCR ligation, and its expression requires both the MAPK and calcineurin signaling pathways
Beno et al., J Biol Chem 1995
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Protein kinase C and mitogen activated protein kinase are required for 1,25-dihydroxyvitamin D3-stimulated Egr induction ... These results suggest that 1 ) D3 stimulates MAPK via a protein kinase C-dependent pathway, 2 ) D3-induced Egr expression can occur via a pathway independent of Ras induced Raf, and 3 ) D3 absolutely requires MAPK activity for Egr expression