Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202125258-202152432)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ MAPK3 ▸ DIABLO ▸ IL1A ▸
BCL6 ▸ BCL3 ▸ BCL9 ▸ BCL5 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK7 ▸ MAPK12 ▸ MAPK4 ▸ MAPK11 ▸ MAPK14 ▸ MAPK13 ▸ MAPK9 ▸
MAPK6 ▸ MAPK10 ▸ MAPK15 ▸ MAPK8 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN2 ▸ CAPN15 ▸ CAPN12 ▸ CAPN6 ▸ FADD ▸
CAPN8 ▸ CAPN11 ▸ CAPN5 ▸ CAPN3 ▸ CAPN9 ▸ CAPN14 ▸ CAPN7 ▸
CAPN13 ▸ IL18 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP2 ▸
MMP9 ▸ MMP14 ▸ MMP12 ▸ MMP3 ▸ MMP11 ▸ MMP16 ▸ MMP20 ▸
NLRP3 ▸ MMP17 ▸ MMP24 ▸ MMP8 ▸ MMP28 ▸ CDKN1A ▸ MMP26 ▸
MMP13 ▸ MMP27 ▸ MMP21 ▸ MMP7 ▸ MMP25 ▸ MMP15 ▸ MMP19 ▸
MMP10 ▸ MMP1 ▸ CASP9 ▸ JUN ▸ PDCD11 ▸ PDCD5 ▸ CASP12 ▸
CFLAR ▸ RNF19A ▸ PDCD1 ▸ PDCD7 ▸ PDCD2 ▸ PDCD6 ▸ PDCD4 ▸
PDCD10 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ CASP2 ▸ ANXA5 ▸
PCBD1 ▸ INS ▸ AHSA1 ▸ TGFB1 ▸ HLA-DRB1 ▸ CASP6 ▸ MPZ ▸
PI3 ▸ NLRC4 ▸ CASP7 ▸ CASP4 ▸ PIK3CA ▸ PIK3R1 ▸ CASP16 ▸
EPO ▸ CASP14 ▸ CASP5 ▸ CASP10 ▸ TNFRSF1A ▸ DDIT3 ▸ PRKCD ▸
DISC2 ▸ TAT ▸ PRDX2 ▸ DISC1 ▸ NOS2 ▸ DFFA ▸ PCNA ▸
GRAP2 ▸ GSK3B ▸ IL6 ▸ CRK ▸ MYLIP ▸ EGF ▸ CTSB ▸
BIRC2 ▸ IL4 ▸ SOD1 ▸ CTNNB1 ▸ IL8 ▸ CAST ▸ NOS1 ▸
IRF1 ▸ EIF2AK2 ▸ VEGFA ▸ BID ▸ PAK2 ▸ LEP ▸ NGF ▸
DFFB ▸ PTGS2 ▸ DNASE1 ▸ ABL1 ▸ P2RX7 ▸ ALPI ▸ ROCK1 ▸
DNASE2 ▸ APP ▸ HGF ▸ RIPK1 ▸ IFI27 ▸ MYC ▸ CDK2 ▸
BCR ▸ MAP3K1 ▸ TCF4 ▸ BDNF ▸ SOD2 ▸ APEH ▸ CAT ▸
IFNB1 ▸ FOS ▸ IL16 ▸ TCF7 ▸ TCF24 ▸ MAP2K1 ▸ NOD2 ▸
IL2 ▸ RAC1 ▸ TCF15 ▸ TCF23 ▸ IL10 ▸ TCF3 ▸ HTRA2 ▸
BMP1 ▸ TCF25 ▸ NOS3 ▸ CSF2 ▸ TCF12 ▸ NFKBIA ▸ CTSD ▸
NOX1 ▸ TCF19 ▸ TLR2 ▸ TCF21 ▸ CA2 ▸ HDAC2 ▸ UPK3B ▸
TCF20 ▸ AIM2 ▸ BAD ▸ ATP5O ▸ CSF3 ▸ ITIH4 ▸ BIRC7 ▸
TLR3 ▸ CD8A ▸ HDAC1 ▸ SOD3 ▸ ADCYAP1 ▸ TLR4 ▸ APOB ▸
ARSK ▸ STAT1 ▸ NOX4 ▸ GAL ▸ MAGT1 ▸ LMNB1 ▸ FGF2 ▸
BMP4 ▸ NLRP1 ▸ BIRC3 ▸ POLDIP2 ▸ PRKDC ▸ CDC73 ▸ HSPA5 ▸
TLR5 ▸ SMPD2 ▸ PPP2CA ▸ NOD1 ▸ SNAP25 ▸ NOX5 ▸ RB1 ▸
STAT3 ▸ AGTR1 ▸ ENDOG ▸ GZMB ▸ BMP2 ▸ BMP6 ▸ IL3 ▸
PPP2R2B ▸ PPP2R1A ▸ CARD8 ▸ BMP5 ▸ KRT18 ▸ PDLIM7 ▸ BMP7 ▸
IL5 ▸ CD79A ▸ HSPB1 ▸ HPR ▸ LEO1 ▸ WDR61 ▸ RIPK2 ▸
TLR7 ▸ IL33 ▸ PML ▸ NOX3 ▸ HMGB1 ▸ PAF1 ▸ IL11 ▸
MST1 ▸ CTR9 ▸ CDK5 ▸ IL15 ▸ BMP15 ▸ TRAF6 ▸ BMP3 ▸
BMP10 ▸ CSE ▸ MAP2K2 ▸ EGFR ▸ TLR10 ▸ IL20 ▸ NPS ▸
BOC ▸ IL24 ▸ APC ▸ PTX4 ▸ CREB3 ▸ CCDC88A ▸ PRNP ▸
CXCL9 ▸ EIF2S1 ▸ LPA ▸ PTX3 ▸ RBBP7 ▸ JAK2 ▸ HTT ▸
IL21 ▸ CD4 ▸ GP9 ▸ PLCG1 ▸ BIRC6 ▸ SYK ▸ ANXA1 ▸
CDC6 ▸ ICAM1 ▸ RBBP4 ▸ WAS ▸ RIPK3 ▸ CDH1 ▸ GP5 ▸
TXN ▸ CREB1 ▸ GSN ▸ TLR1 ▸ MET ▸ HIF1A ▸ PGP ▸
PPARA ▸ TNFRSF1B ▸ TLR8 ▸ IGF2 ▸ RAD51 ▸ CREB5 ▸ GP6 ▸
GP2 ▸ LMNB2 ▸ LYN ▸ ROCK2 ▸ SMARCD1 ▸ TRAF1 ▸ MUC1 ▸
IL22 ▸ MUC4 ▸ MUC17 ▸ HMOX1 ▸ SMARCB1 ▸ ARID1A ▸ PPARG ▸
IL9 ▸ MUC12 ▸ CARD11 ▸ IL7 ▸ MUC21 ▸ CD79B ▸ MUC8 ▸
SMARCE1 ▸ KDR ▸ MUC2 ▸ RRAS ▸ SMARCA2 ▸ SMARCC2 ▸ ACTL6A ▸
SMPD1 ▸ CARD9 ▸ SYT1 ▸ CARD6 ▸ SMARCD2 ▸ MDM2 ▸ SMARCA4 ▸
IL37 ▸ MSC ▸ IKBKB ▸ FOXO3 ▸ MUC13 ▸ IL13 ▸ IL31 ▸
MUC6 ▸ GATA1 ▸ RAF1 ▸ CCND1 ▸ ACHE ▸ IL34 ▸ UCN ▸
MUC15 ▸ IL32 ▸ CDK8 ▸ TLR9 ▸ CCL2 ▸ TLR6 ▸ CDA ▸
PAK1 ▸ HSPD1 ▸ PLD1 ▸ SMARCC1 ▸ MUC16 ▸ ABCC6 ▸ MUC20 ▸
RENBP ▸ TOP1 ▸ STX1A ▸ IL26 ▸ IL19 ▸ ANGPT2 ▸ IL27 ▸
IL25 ▸ BECN1 ▸ MUC19 ▸ MUC22 ▸ BRCA1 ▸ MUC7 ▸ IRF3 ▸
MEFV ▸ PRKACB ▸ IRF2 ▸ CEP78 ▸ RASA1 ▸ CEP97 ▸ MAP2K6 ▸
DES ▸ GDNF ▸ TRAF2 ▸ SLCO6A1 ▸ DST ▸ BCL2L12 ▸ CD40 ▸
PRKCA ▸ CARD14 ▸ ANGPT1 ▸ MAP2K4 ▸ BIRC5 ▸ ELAVL1 ▸ SLC17A5 ▸
CEP135 ▸ CEP19 ▸ HSF1 ▸ E2F1 ▸ BIRC8 ▸ CEP164 ▸ CEP128 ▸
VCP ▸ HSP90AA1 ▸ CEP152 ▸ SKP1 ▸ CEP70 ▸ HIP1 ▸ CEP104 ▸
CEP76 ▸ WNT1 ▸ BACE1 ▸ EHMT1 ▸ GRB7 ▸ IGF1R ▸ LAT ▸
DERL1 ▸ SP1 ▸ VIM ▸ MPST ▸ NUP214 ▸ TARDBP ▸ NUP153 ▸
IRF5 ▸ MAP2K3 ▸ PTEN ▸ PRKAR1A ▸ GRK7 ▸ PIDD ▸ CARD17 ▸
ATG5 ▸ MAP2K7 ▸ CEP95 ▸ CEP85 ▸ ME2 ▸ ALB ▸ GRK1 ▸
CARD18 ▸ GRK5 ▸ PSEN1 ▸ PTHLH ▸ CEP250 ▸ IL1RN ▸ TRAF3 ▸
HUNK ▸ NUP62 ▸ GRK6 ▸ PRKAR1B ▸ CEP55 ▸ VDAC1 ▸ CUL1 ▸
PXN ▸ CALM3 ▸ ADIPOQ ▸ CARD10 ▸ CEP72 ▸ PLOD2 ▸ MAP2K5 ▸
PRKAR2A ▸ PANX1 ▸ SLC9A1 ▸ PRKCG ▸ MEPE ▸ GRK4 ▸ GRB2 ▸
ARSA ▸ CD47 ▸ TNFRSF10A ▸ CEP290 ▸ PEA15 ▸ EPX ▸ NUP210 ▸
SEC14L2 ▸ CEP63 ▸ CEP89 ▸ PTK2 ▸ CEP112 ▸ CEP41 ▸ GRB14 ▸
CDK4 ▸ H2AFX ▸ PLD2 ▸ SOAT1 ▸ CEP120 ▸ GUCY2D ▸ HIST2H2BE ▸
CARD16 ▸ PSMD10 ▸ PRKACG ▸ CCR7 ▸ IRF4 ▸ SETD2 ▸ GRB10 ▸
PRKAR2B ▸ NPM1 ▸ CEP44 ▸ CEP57 ▸ CEP192 ▸ CEP350 ▸ TCHP ▸
CEP68 ▸ VIMP ▸ SETBP1 ▸ ARC ▸ ALK ▸ LYPLA1 ▸ FOXO1 ▸
NPY6R ▸ MIF ▸ IKBKG ▸ PTBP1 ▸ CEP170 ▸ PAN2 ▸ PLD6 ▸
RANBP2 ▸ TGM2 ▸ MED6 ▸ APIP ▸ MAP3K7 ▸ MLYCD ▸ TNFRSF10B ▸
SREBF1 ▸ CDK17 ▸ MTOR ▸ BLM ▸ PAEP ▸ JAK1 ▸ PMEL ▸
RHO ▸ TNFRSF8 ▸ FAF1 ▸ CCR8 ▸ SERPINA1 ▸ APOE ▸ ACAD8 ▸
DAXX ▸ MT3 ▸ ODC1 ▸ HTRA3 ▸ S100A12 ▸ HTRA4 ▸ TET2 ▸
IRF8 ▸ CDK12 ▸ BNIP3 ▸ TNFSF12 ▸ MED17 ▸ NUAK1 ▸ NUP43 ▸
SERPINF1 ▸ CCR2 ▸ NPPA ▸ TGFB3 ▸ VIP ▸ CCR1 ▸ MST1R ▸
RAD21 ▸ APOBEC3D ▸ CD2 ▸ SUB1 ▸ WNT3A ▸ TMED7 ▸ GYS2 ▸
IARS ▸ ZGLP1 ▸ CDK9 ▸ WNK1 ▸ NTF3 ▸ PRKAB2 ▸ PLD4 ▸
MED15 ▸ PTCH1 ▸ IFIH1 ▸ HRD ▸ RAD52 ▸ CTRL ▸ CCNH ▸
PARG ▸ HDAC6 ▸ CDK20 ▸ LRP1 ▸ CCNC ▸ RAD50 ▸ CYR61 ▸
CDK10 ▸ MED7 ▸ IDO1 ▸ ITCH ▸ ADM ▸ CTSL ▸ CFL1 ▸
EMP3 ▸ CALR ▸ RAD18 ▸ ANXA6 ▸ SLPI ▸ SMAD3 ▸ RBL2 ▸
PRKAA2 ▸ EDNRA ▸ CCR5 ▸ MED23 ▸ E2F2 ▸ PC ▸ HIPK2 ▸
EIF4G3 ▸ GPI ▸ GNRH1 ▸ PAN3 ▸ CDK19 ▸ MED13 ▸ MED14 ▸
SDS ▸ GHSR ▸ TSC22D3 ▸ NANOS2 ▸ CDK6 ▸ ATF2 ▸ CISH ▸
E2F3 ▸ CPA1 ▸ XAF1 ▸ EIF4G1 ▸ KLF4 ▸ SMAD7 ▸ DAP3 ▸
APEX1 ▸ RAB5A ▸ MED8 ▸ PRG4 ▸ SHC1 ▸ ACSM3 ▸ IRF7 ▸
AIP ▸ TRAF5 ▸ C22orf29 ▸ IFNA2 ▸ PNPLA2 ▸ SMAD4 ▸ VDAC3 ▸
NAIP ▸ SERPINB9 ▸ NLRP5 ▸ NLRC5 ▸ PRKAG2 ▸ CDK1 ▸ CD8B ▸
GYS1 ▸ MED1 ▸ THBS1 ▸ CIB1 ▸ XRCC6 ▸ CTNNBL1 ▸ DHCR24 ▸
STX2 ▸ CXCL17 ▸ DLG1 ▸ NTF4 ▸ CCR3 ▸ ID3 ▸ TIMP3 ▸
ETS1 ▸ CDK16 ▸ NTN1 ▸ CA8 ▸ TAC4 ▸ TFAP2A ▸ SATB1 ▸
IAPP ▸ CCL19 ▸ GJA1 ▸ PTPN11 ▸ CENPK ▸ GLI1 ▸ GPX1 ▸
MAP2 ▸ CDC42 ▸ MED12 ▸ DIDO1 ▸ CFTR ▸ KLK3 ▸ CSF1 ▸
QRICH2 ▸ SRC ▸ FAM168B ▸ RARA ▸ GNA11 ▸ CALML3 ▸ KMT2A ▸
PRKAB1 ▸ ERVK-6 ▸ RAD1 ▸ ATF5 ▸ MICE ▸ TRAF4 ▸ CCK ▸
PRG2 ▸ NACA ▸ ADH5 ▸ SAA1 ▸ CDK3 ▸ EMP1 ▸ MED25 ▸
RAC2 ▸ PSENEN ▸ RAC3 ▸ CALB1 ▸ HRK ▸ CCR4 ▸ JAK3 ▸
PLD3 ▸ MTA2 ▸ DAPK2 ▸ HTRA1 ▸ STSP1 ▸ GRP ▸ NANOG ▸
CTNND1 ▸ HDAC4 ▸ RAD17 ▸ ATG3 ▸ TET1 ▸ RUNX3 ▸ SREBF2 ▸
CDK15 ▸ PPP1R3A ▸ TAC1 ▸ BAG3 ▸ MED4 ▸ SEPT4 ▸ GSTT1 ▸
ETS2 ▸ CAPNS1 ▸ ING1 ▸ LGALS1 ▸ DYRK1A ▸ PRG3 ▸ IRS1 ▸
PLK1 ▸ GPX3 ▸ MT4 ▸ MME ▸ CRYAB ▸ CCR10 ▸ NR0B1 ▸
CDK14 ▸ FUT1 ▸ CCR9 ▸ EEF1A2 ▸ ABCD1 ▸ FHIT ▸ COP ▸
BCAP31 ▸ PPT1 ▸ PSMB9 ▸ LRRC59 ▸ TRA ▸ CDK18 ▸ EML2 ▸
PRKAA1 ▸ CCR6 ▸ PLD5 ▸ EIF4G2 ▸ TAC3 ▸ MTA1 ▸ SPP1 ▸
CXCL13 ▸ CDK7 ▸ MED21 ▸ AFP ▸ UCP2 ▸ CDCA5 ▸ IGFBP3 ▸
MED24 ▸ MTA3 ▸ CHUK ▸ PGF ▸ VDAC2 ▸ HMGCR ▸ STC1 ▸
DNAJC5 ▸ PRKAG1 ▸ MED26 ▸ QRICH1 ▸ CDK13 ▸ ANG ▸ SERP2 ▸
ACIN1 ▸ KLKB1 ▸ ANP32A ▸ TRAF7 ▸ TYR ▸ NLRP7 ▸ ATM ▸
SIVA1 ▸ EMP2 ▸ CPOX ▸ IRF9 ▸ NAB1 ▸ FOXP3 ▸ HCLS1 ▸
NAB2 ▸ IFI44 ▸ PDGFB ▸ PIN1 ▸ RIPK4 ▸ TET3 ▸ UBC ▸
COPS6 ▸ TRIM25 ▸ COL6A1 ▸ COL3A1 ▸ TFCP2 ▸ RNF135 ▸ CLIP3 ▸
KHDRBS1 ▸ SQSTM1 ▸ EP300 ▸ GRIA1 ▸ COL5A1 ▸ IL1R2 ▸ PICALM ▸
COL4A6 ▸ PDIA6 ▸ IFT57 ▸ MAP4K4 ▸ ITGAV ▸ CASP8AP2 ▸ TNFAIP3 ▸
CD3E ▸ PLEC ▸ BNIP3L ▸ ITGB1 ▸ UBB ▸ TNFRSF25 ▸ CRADD ▸
USP54 ▸ CUL3 ▸ COL4A4 ▸ RALBP1 ▸ KARS ▸ CDK11A ▸ SORBS1 ▸
PIDD1 ▸ UBE2D1 ▸ RAB10 ▸ TOPORS ▸ CLTC ▸ KRR1 ▸ TUBA1A ▸
IL1R1 ▸ COL4A1 ▸ SYF2 ▸ CD247 ▸ TICAM2 ▸ COL4A5 ▸ TRIM28 ▸
MYO9A ▸ COL11A2 ▸ ARHGDIA ▸ CDK11B ▸ HIST1H4A ▸ IQGAP1 ▸ TUBA1C ▸
MSN ▸ NCL ▸ COL5A2 ▸ PARK7 ▸ CD3D ▸ USP2 ▸ ATG4D ▸
ATAD3A ▸ IRS4 ▸ ACTG2 ▸ TUBB ▸ COL2A1 ▸ COL1A1 ▸ NUCB1 ▸
EDA2R ▸ NOL3 ▸ LY96 ▸ DNAJC7 ▸ NEFH ▸ COL6A3 ▸ UBE2L3 ▸
STK24 ▸ MAPT ▸ MAP1LC3A ▸ NR1H4 ▸ TNFSF14 ▸ COL11A1 ▸ FIS1 ▸
COL1A2 ▸ ATN1 ▸ AR ▸ BFAR ▸ DDX28 ▸ ITGA2 ▸ COL6A2 ▸
PLA2G4B ▸ PTPN6 ▸ RNF34 ▸ DEDD2 ▸ EIF3S10 ▸ OTUD7B ▸ CD14 ▸
PRKCI ▸ PTPN13 ▸ EIF4A1 ▸ HNRNPH2 ▸ COL4A3 ▸ COL7A1 ▸ ACTA2 ▸
MAP3K14 ▸ NUCB2 ▸ ITGB3 ▸ CD3G ▸ UBR5 ▸ RPS27 ▸ PLIN4 ▸
CHD3 ▸ MAP1LC3B ▸ PIAS1 ▸ SPARC ▸ RALGDS ▸ RPS27L ▸ MALT1 ▸
PCYT1A ▸ PARK2 ▸ YES1 ▸ PYCARD ▸ EZR ▸
Data information
Please see the Gene Interactions Track Manual.