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Gene interactions and pathways from curated databases and text-mining
Neuron 1998, PMID: 9808472

Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation.

Impey, S; Obrietan, K; Wong, S T; Poser, S; Yano, S; Wayman, G; Deloulme, J C; Chan, G; Storm, D R

Although Ca2+-stimulated cAMP response element binding protein- (CREB-) dependent transcription has been implicated in growth, differentiation, and neuroplasticity, mechanisms for Ca2+-activated transcription have not been defined. Here, we report that extracellular signal-related protein kinase (ERK) signaling is obligatory for Ca2+-stimulated transcription in PC12 cells and hippocampal neurons. The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB. Interestingly, the Ca2+-induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation. This may explain why PKA activity is required for Ca2+-stimulated CREB-dependent transcription. Furthermore, the full expression of the late phase of long-term potentiation (L-LTP) and L-LTP-associated CRE-mediated transcription requires ERK activation, suggesting that the activation of CREB by ERK plays a critical role in the formation of long lasting neuronal plasticity.

Diseases/Pathways annotated by Medline MESH: Calcium Signaling
Document information provided by NCBI PubMed

Text Mining Data

Rsk2 → Ca2+: " The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB "

Ca2+ → ERK: " The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB "

CREB → Rsk2: " The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB "

CREB → Ca2+: " The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB "

CREB → ERK: " The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB "

Rsk2 → Ca2+: " Interestingly, the Ca2+ induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation "

Rsk2 → protein kinase A (PKA): " Interestingly, the Ca2+ induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation "

ERK → Ca2+: " Interestingly, the Ca2+ induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation "

ERK → protein kinase A (PKA): " Interestingly, the Ca2+ induced nuclear translocation of ERK and Rsk2 to the nucleus requires protein kinase A (PKA) activation "

CREB → ERK: " Furthermore, the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation, suggesting that the activation of CREB by ERK plays a critical role in the formation of long lasting neuronal plasticity "

Manually curated Databases

No curated data.