Gene interactions and pathways from curated databases and text-mining
Cell 1998, PMID: 9708738

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.

McMahon, S B; Van Buskirk, H A; Dugan, K A; Copeland, T D; Cole, M D

The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.

Diseases/Pathways annotated by Medline MESH: Cell Transformation, Neoplastic
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Text Mining Data

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Manually curated Databases

  • IRef Biogrid Interaction: TRRAP — MAX (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYC — TRRAP (direct interaction, pull down)
  • IRef Biogrid Interaction: MYC — MAX (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRRAP — E2F1 (physical association, affinity chromatography technology)
  • IRef Dip Interaction: MAX — TRRAP (physical association, two hybrid)
  • IRef Dip Interaction: MYC — TRRAP (physical association, coimmunoprecipitation)
  • IRef Dip Interaction: MYC — MAX (physical association, coimmunoprecipitation)
  • IRef Hprd Interaction: TRRAP — MYC (in vivo)
  • IRef Hprd Interaction: TRRAP — MYC (in vitro)
  • IRef Hprd Interaction: TRRAP — E2F1 (in vivo)
  • IRef Intact Interaction: MYC — TRRAP (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: MYC — TRRAP (physical association, coimmunoprecipitation)
  • NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → TAF10 (TAF10) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → TAF12 (TAF12) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → SPT3 (SUPT3H) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → MYC/Max complex (MYC-MAX) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → TAF9 (TAF9) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → TAF12 (TAF12) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → SPT3 (SUPT3H) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → MYC/Max complex (MYC-MAX) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → TAF9 (TAF9) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → SPT3 (SUPT3H) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → MYC/Max complex (MYC-MAX) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → TAF9 (TAF9) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: SPT3 (SUPT3H) → MYC/Max complex (MYC-MAX) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: SPT3 (SUPT3H) → TAF9 (TAF9) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: SPT3 (SUPT3H) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: SPT3 (SUPT3H) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: MYC/Max complex (MYC-MAX) → TAF9 (TAF9) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: MYC/Max complex (MYC-MAX) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: MYC/Max complex (MYC-MAX) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF9 (TAF9) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: TAF9 (TAF9) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database C-MYC pathway: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction
In total, 46 gene pairs are associated to this article in curated databases