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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Shi Yan Sheng Wu Xue Bao 1996, PMID: 9639807

[Co-regulative effect of PKA-RII and PKC-alpha kinase subspecies on expression of c-myc and c-H-ras in human gastric cancer cells (MGC 80-3)].

Wang, D S; Liang, Y Y; Peng, J

Based on preceding experiment, we further studied the co-regulative effects of PKA-R II and PKC-alpha on expression of oncogenes in human gastric cell line MGC 80-3. The c-myc and c-H-ras expression were suppressed in MGC 80-3 cells during HMBA-induced differentiation. At the same time, PKA-R II showed nuclear translocation from cytoplasm, whereas the expression of PKC-alpha shifted from nucleus to cytoplasm. PKA inhibitor (Sigma) was added to block cAMP-PKA pathway when cell differentiation were induced by HMBA. The PKA-R II was still located in cytoplasm but expression of PKC-alpha translocated again into nucleus. Meanwhile, the c-myc and c-H-ras again expressed. This suggested that the changing regulation of oncogene expression were closely related to signalling from nuclear translocation of kinase subspecies. It thus shows the co-regulation effects of two signal system on oncogenes expression.

Diseases/Pathways annotated by Medline MESH: Stomach Neoplasms
Document information provided by NCBI PubMed

Text Mining Data

c-H-ras — PKA-RII: " [ Co-regulative effect of PKA-RII and PKC-alpha kinase subspecies on expression of c-myc and c-H-ras in human gastric cancer cells ( MGC 80-3 ) ] "

Manually curated Databases

No curated data.