Gene interactions and pathways from curated databases and text-mining
Science 1995, PMID: 8533096

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.

Yamaguchi, K; Shirakabe, K; Shibuya, H; Irie, K; Oishi, I; Ueno, N; Taniguchi, T; Nishida, E; Matsumoto, K

The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members.

Document information provided by NCBI PubMed

Text Mining Data

TAK1 → bone morphogenetic protein: " Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein "

Manually curated Databases

  • NCI Pathway Database TGF-beta receptor signaling: TAK1/XIAP complex (MAP3K7-XIAP) → XIAP (XIAP) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database TGF-beta receptor signaling: TAK1/XIAP complex (MAP3K7-XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database TGF-beta receptor signaling: XIAP (XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database TGF-beta receptor signaling: XIAP (XIAP) → TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • Reactome Reaction: TAB1 → MAP2K6 (reaction)
  • Reactome Reaction: TRAF6 → MAP2K3 (reaction)
  • Reactome Reaction: NOD2 → MAP2K6 (reaction)
  • Reactome Reaction: IRAK2 → MAP2K7 (reaction)
  • Reactome Reaction: MAP2K7 → TAB1 (reaction)
  • Reactome Reaction: MAP2K4 → IKBKG (reaction)
  • Reactome Reaction: MAP2K7 → TAB2 (reaction)
  • Reactome Reaction: MAP2K4 → TRAF6 (reaction)
  • Reactome Reaction: MAP2K7 → IRAK1 (reaction)
  • Reactome Reaction: MAP2K3 → TAB2 (reaction)
  • Reactome Reaction: TRAF6 → MAP2K6 (reaction)
  • Reactome Reaction: MAP2K7 → MAP3K7 (reaction)
  • Reactome Reaction: MAP2K7 → IKBKG (reaction)
  • Reactome Reaction: MAP2K3 → IRAK1 (reaction)
  • Reactome Reaction: MAP2K6 → MAP3K7 (reaction)
  • Reactome Reaction: MAP2K7 → TRAF6 (reaction)
  • Reactome Reaction: MAP2K3 → TAB3 (reaction)
  • Reactome Reaction: MAP2K4 → MAP3K7 (reaction)
  • Reactome Reaction: IRAK2 → MAP2K4 (reaction)
  • Reactome Reaction: IKBKG → MAP2K3 (reaction)
  • Reactome Reaction: IKBKG → MAP2K6 (reaction)
  • Reactome Reaction: NOD1 → MAP2K7 (reaction)
  • Reactome Reaction: MAP2K3 → MAP3K7 (reaction)
  • Reactome Reaction: MAP2K4 → TAB3 (reaction)
  • Reactome Reaction: MAP2K4 → TAB1 (reaction)
  • Reactome Reaction: IRAK2 → MAP2K3 (reaction)
  • Reactome Reaction: MAP2K7 → TAB3 (reaction)
  • Reactome Reaction: MAP2K4 → TAB2 (reaction)
  • Reactome Reaction: NOD1 → MAP2K6 (reaction)
  • Reactome Reaction: MAP2K6 → TAB3 (reaction)
  • Reactome Reaction: TAB1 → MAP2K3 (reaction)
  • Reactome Reaction: NOD2 → MAP2K4 (reaction)
  • Reactome Reaction: NOD1 → MAP2K4 (reaction)
  • Reactome Reaction: MAP2K7 → RIPK2 (reaction)
  • Reactome Reaction: IRAK2 → MAP2K6 (reaction)
  • Reactome Reaction: NOD2 → MAP2K3 (reaction)
  • Reactome Reaction: NOD1 → MAP2K3 (reaction)
  • Reactome Reaction: RIPK2 → MAP2K6 (reaction)
  • Reactome Reaction: MAP2K4 → IRAK1 (reaction)
  • Reactome Reaction: MAP2K6 → IRAK1 (reaction)
  • Reactome Reaction: NOD2 → MAP2K7 (reaction)
  • Reactome Reaction: MAP2K6 → TAB2 (reaction)
  • Reactome Reaction: MAP2K4 → RIPK2 (reaction)
  • Reactome Reaction: RIPK2 → MAP2K3 (reaction)
In total, 61 gene pairs are associated to this article in curated databases