Gene interactions and pathways from curated databases and text-mining
Science 1995, PMID: 7878466

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.

Brown, K; Gerstberger, S; Carlson, L; Franzoso, G; Siebenlist, U

I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm. Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha. This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism. Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and requires the proteolysis of this inhibitor. When either serine-32 or serine-36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation or degradation, and NF-kappa B could not be activated. These results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B.

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Text Mining Data

NF-kappa B ⊣ I kappa B-alpha: " I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm "

Manually curated Databases

  • NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/ELKS complex (CHUK-IKBKB-IKBKG-ERC1) → IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) (modification, activates)
    Evidence: assay, physical interaction
  • NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/ELKS complex (CHUK-IKBKB-IKBKG-ERC1) → NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA) (modification, activates)
    Evidence: assay, physical interaction
  • NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/ELKS complex (CHUK-IKBKB-IKBKG-ERC1) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
    Evidence: assay, physical interaction
  • NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) → NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA) (modification, activates)
    Evidence: assay, physical interaction
  • NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
    Evidence: assay, physical interaction
In total, 31 gene pairs are associated to this article in curated databases