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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Nucleic Acids Res 2012, PMID: 22904065

p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.

Yagi, Mikako; Uchiumi, Takeshi; Takazaki, Shinya; Okuno, Bungo; Nomura, Masatoshi; Yoshida, Shin-ichi; Kanki, Tomotake; Kang, Dongchon

p32 is an evolutionarily conserved and ubiquitously expressed multifunctional protein. Although p32 exists at diverse intra and extracellular sites, it is predominantly localized to the mitochondrial matrix near the nucleoid associated with mitochondrial transcription factor A. Nonetheless, its function in the matrix is poorly understood. Here, we determined p32 function via generation of p32-knockout mice. p32-deficient mice exhibited mid-gestation lethality associated with a severe developmental defect of the embryo. Primary embryonic fibroblasts isolated from p32-knockout embryos showed severe dysfunction of the mitochondrial respiratory chain, because of severely impaired mitochondrial protein synthesis. Recombinant p32 binds RNA, not DNA, and endogenous p32 interacts with all mitochondrial messenger RNA species in vivo. The RNA-binding ability of p32 is well correlated with the mitochondrial translation. Co-immunoprecipitation revealed the close association of p32 with the mitoribosome. We propose that p32 is required for functional mitoribosome formation to synthesize proteins within mitochondria.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: ERAL1 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPL22 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS26 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPL38 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPS10 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS34 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPS25 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPL44 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS5 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — TFB2M (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPS30 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — PTCD3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS27 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPL19 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — PHB2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPL12 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS9 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — TUFM (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPS23 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — HSPD1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPL18 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPL45 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TFAM — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — DAP3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — PHB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPS28 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CLPX — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — LRPPRC (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — HSPA9 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — TSFM (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPS22 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — LONP1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — TRAP1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPL3 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPL4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — MRPL21 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPL46 — C1QBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QBP — HSPA8 (physical association, affinity chromatography technology)
  • IRef Intact Interaction: Complex of MRPS22-MRPL3-TFAM-DAP3 (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 40 proteins (association, cross-linking study)
In total, 784 gene pairs are associated to this article in curated databases