Gene interactions and pathways from curated databases and text-mining
Immunity 2010, PMID: 21074459

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.

Tsuchida, Tetsuo; Zou, Jian; Saitoh, Tatsuya; Kumar, Himanshu; Abe, Takayuki; Matsuura, Yoshiharu; Kawai, Taro; Akira, Shizuo

The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I interferon (IFN) and other cytokines. Here, we identified interferon-inducible tripartite-motif (TRIM) 56 as a regulator of double-stranded DNA-mediated type I interferon induction. TRIM56 overexpression enhanced IFN-β promoter activation after double-stranded DNA stimulation whereas TRIM56 knockdown abrogated it. TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination. This modification induced STING dimerization, which was a prerequisite for recruitment of the antiviral kinase TBK1 and subsequent induction of IFN-β. Taken together, these results indicate that TRIM56 is an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses.

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Text Mining Data

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Manually curated Databases

  • IRef Biogrid Interaction: UBC — TMEM173 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRIM56 — TMEM173 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TMEM173 — TMEM173 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TBK1 — TMEM173 (physical association, affinity chromatography technology)
  • Reactome Reaction: TRIM32 → UBA52 (reaction)
  • Reactome Reaction: TRIM32 → TMEM173 (direct_complex)
  • Reactome Reaction: TRIM56 → TRIM56 (reaction)
  • Reactome Reaction: TRIM56 → UBC (reaction)
  • Reactome Reaction: TRIM32 → TRIM56 (reaction)
  • Reactome Reaction: TRIM32 → RPS27A (reaction)
  • Reactome Reaction: RPS27A → TRIM56 (reaction)
  • Reactome Reaction: TRIM32 → TMEM173 (reaction)
  • Reactome Reaction: UBA52 → TRIM56 (reaction)
  • Reactome Reaction: TRIM32 → UBC (reaction)
  • Reactome Reaction: UBA52 → TMEM173 (reaction)
  • Reactome Reaction: TMEM173 → TRIM56 (direct_complex)
  • Reactome Reaction: TRIM32 → TRIM32 (reaction)
  • Reactome Reaction: TMEM173 → TMEM173 (reaction)
  • Reactome Reaction: TRIM56 → UBB (reaction)
  • Reactome Reaction: TMEM173 → UBB (reaction)
  • Reactome Reaction: TMEM173 → TRIM56 (reaction)
  • Reactome Reaction: RPS27A → TMEM173 (reaction)
  • Reactome Reaction: TMEM173 → UBC (reaction)
  • Reactome Reaction: TRIM32 → UBB (reaction)
In total, 19 gene pairs are associated to this article in curated databases