Gene interactions and pathways from curated databases and text-mining
EMBO J 2009, PMID: 19851281

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules.

Howe, Christopher; Garstka, Malgorzata; Al-Balushi, Mohammed; Ghanem, Esther; Antoniou, Antony N; Fritzsche, Susanne; Jankevicius, Gytis; Kontouli, Nasia; Schneeweiss, Clemens; Williams, Anthony; Elliott, Tim; Springer, Sebastian

Calreticulin is a lectin chaperone of the endoplasmic reticulum (ER). In calreticulin-deficient cells, major histocompatibility complex (MHC) class I molecules travel to the cell surface in association with a sub-optimal peptide load. Here, we show that calreticulin exits the ER to accumulate in the ER-Golgi intermediate compartment (ERGIC) and the cis-Golgi, together with sub-optimally loaded class I molecules. Calreticulin that lacks its C-terminal KDEL retrieval sequence assembles with the peptide-loading complex but neither retrieves sub-optimally loaded class I molecules from the cis-Golgi to the ER, nor supports optimal peptide loading. Our study, to the best of our knowledge, demonstrates for the first time a functional role of intracellular transport in the optimal loading of MHC class I molecules with antigenic peptide.

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Text Mining Data

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Manually curated Databases

  • Reactome Reaction: HLA-F → TAP2 (reaction)
  • Reactome Reaction: HLA-G → PDIA3 (reaction)
  • Reactome Reaction: HLA-B → TAPBP (reaction)
  • Reactome Reaction: HLA-F → TAP1 (reaction)
  • Reactome Reaction: CALR → TAP1 (reaction)
  • Reactome Reaction: TAP1 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAPBP (reaction)
  • Reactome Reaction: CALR → PDIA3 (reaction)
  • Reactome Reaction: HLA-C → TAP1 (reaction)
  • Reactome Reaction: HLA-A → TAPBP (reaction)
  • Reactome Reaction: HLA-G → TAP2 (reaction)
  • Reactome Reaction: CALR → TAPBP (reaction)
  • Reactome Reaction: HLA-C → CALR (reaction)
  • Reactome Reaction: HLA-C → TAPBP (reaction)
  • Reactome Reaction: HLA-G → TAPBP (reaction)
  • Reactome Reaction: TAP2 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAP2 (reaction)
  • Reactome Reaction: HLA-A → CALR (reaction)
  • Reactome Reaction: B2M → TAP1 (reaction)
  • Reactome Reaction: HLA-F → PDIA3 (reaction)
  • Reactome Reaction: HLA-B → PDIA3 (reaction)
  • Reactome Reaction: CALR → HLA-G (reaction)
  • Reactome Reaction: CALR → TAP2 (reaction)
  • Reactome Reaction: HLA-A → TAP1 (reaction)
  • Reactome Reaction: HLA-C → TAP2 (reaction)
  • Reactome Reaction: B2M → PDIA3 (reaction)
  • Reactome Reaction: HLA-F → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAP1 (reaction)
  • Reactome Reaction: CALR → HLA-E (reaction)
  • Reactome Reaction: B2M → TAPBP (reaction)
  • Reactome Reaction: B2M → TAP2 (reaction)
  • Reactome Reaction: B2M → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAPBP (reaction)
  • Reactome Reaction: HLA-A → PDIA3 (reaction)
  • Reactome Reaction: CALR → HLA-F (reaction)
  • Reactome Reaction: HLA-A → TAP2 (reaction)
  • Reactome Reaction: HLA-E → PDIA3 (reaction)
  • Reactome Reaction: HLA-B → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAP1 (reaction)
  • Reactome Reaction: HLA-B → TAP1 (reaction)
  • Reactome Reaction: PDIA3 → TAP2 (reaction)
  • Reactome Reaction: HLA-B → TAP2 (reaction)
  • Reactome Reaction: HLA-C → PDIA3 (reaction)
  • Reactome Reaction: HLA-G → TAP1 (reaction)
In total, 44 gene pairs are associated to this article in curated databases