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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Immunity 2009, PMID: 19119025

Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.

Dong, Gang; Wearsch, Pamela A; Peaper, David R; Cresswell, Peter; Reinisch, Karin M

Tapasin is a glycoprotein critical for loading major histocompatibility complex (MHC) class I molecules with high-affinity peptides. It functions within the multimeric peptide-loading complex (PLC) as a disulfide-linked, stable heterodimer with the thiol oxidoreductase ERp57, and this covalent interaction is required to support optimal PLC activity. Here, we present the 2.6 A resolution structure of the tapasin-ERp57 core of the PLC. The structure revealed that tapasin interacts with both ERp57 catalytic domains, accounting for the stability of the heterodimer, and provided an example of a protein disulfide isomerase family member interacting with substrate. Mutational analysis identified a conserved surface on tapasin that interacted with MHC class I molecules and was critical for peptide loading and editing functions of the tapasin-ERp57 heterodimer. By combining the tapasin-ERp57 structure with those of other defined PLC components, we present a molecular model that illuminates the processes involved in MHC class I peptide loading.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: HLA-F → TAP2 (reaction)
  • Reactome Reaction: HLA-G → TAP1 (indirect_complex)
  • Reactome Reaction: CALR → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-B → TAPBP (reaction)
  • Reactome Reaction: HLA-F → TAP1 (reaction)
  • Reactome Reaction: HLA-F → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-E → TAP1 (indirect_complex)
  • Reactome Reaction: B2M → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-F → TAP1 (indirect_complex)
  • Reactome Reaction: CALR → TAP1 (reaction)
  • Reactome Reaction: TAP1 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAPBP (reaction)
  • Reactome Reaction: B2M → CALR (indirect_complex)
  • Reactome Reaction: CALR → PDIA3 (reaction)
  • Reactome Reaction: HLA-C → TAP1 (reaction)
  • Reactome Reaction: HLA-A → TAPBP (reaction)
  • Reactome Reaction: HLA-G → TAP2 (reaction)
  • Reactome Reaction: CALR → TAPBP (reaction)
  • Reactome Reaction: TAP1 → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-C → CALR (reaction)
  • Reactome Reaction: HLA-B → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-B → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-C → TAPBP (reaction)
  • Reactome Reaction: HLA-B → TAPBP (indirect_complex)
  • Reactome Reaction: PDIA3 → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-G → TAPBP (reaction)
  • Reactome Reaction: TAP2 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAP2 (reaction)
  • Reactome Reaction: HLA-A → CALR (reaction)
  • Reactome Reaction: HLA-A → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-A → CALR (indirect_complex)
  • Reactome Reaction: B2M → TAP1 (reaction)
  • Reactome Reaction: B2M → TAPBP (indirect_complex)
  • Reactome Reaction: CALR → TAPBP (direct_complex)
  • Reactome Reaction: CALR → HLA-G (reaction)
  • Reactome Reaction: CALR → TAP2 (reaction)
  • Reactome Reaction: HLA-A → TAP1 (reaction)
  • Reactome Reaction: B2M → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-C → TAP2 (reaction)
  • Reactome Reaction: CALR → PDIA3 (indirect_complex)
  • Reactome Reaction: HLA-C → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-F → TAPBP (reaction)
  • Reactome Reaction: CALR → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-E → TAP1 (reaction)
  • Reactome Reaction: PDIA3 → TAP2 (indirect_complex)
  • Reactome Reaction: CALR → HLA-E (indirect_complex)
  • Reactome Reaction: CALR → HLA-E (reaction)
  • Reactome Reaction: B2M → TAPBP (reaction)
  • Reactome Reaction: HLA-C → CALR (indirect_complex)
  • Reactome Reaction: B2M → TAP2 (reaction)
  • Reactome Reaction: HLA-F → TAP2 (indirect_complex)
  • Reactome Reaction: CALR → HLA-F (indirect_complex)
  • Reactome Reaction: HLA-E → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-G → TAP2 (indirect_complex)
  • Reactome Reaction: B2M → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAPBP (reaction)
  • Reactome Reaction: HLA-A → TAP1 (indirect_complex)
  • Reactome Reaction: CALR → HLA-F (reaction)
  • Reactome Reaction: HLA-C → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-A → TAP2 (reaction)
  • Reactome Reaction: HLA-C → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-A → TAP2 (indirect_complex)
  • Reactome Reaction: TAP2 → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-B → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-E → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-G → TAPBP (indirect_complex)
  • Reactome Reaction: PDIA3 → TAP1 (reaction)
  • Reactome Reaction: HLA-B → TAP1 (reaction)
  • Reactome Reaction: PDIA3 → TAP2 (reaction)
  • Reactome Reaction: HLA-B → TAP2 (reaction)
  • Reactome Reaction: CALR → HLA-G (indirect_complex)
  • Reactome Reaction: HLA-B → CALR (indirect_complex)
  • Reactome Reaction: HLA-G → TAP1 (reaction)
In total, 37 gene pairs are associated to this article in curated databases