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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Cell 2007, PMID: 17719541

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.

Das, Sanjeev; Raj, Lakshmi; Zhao, Bo; Kimura, Yuki; Bernstein, Alan; Aaronson, Stuart A; Lee, Sam W

A critical unresolved issue about the genotoxic stress response is how the resulting activation of the p53 tumor suppressor can lead either to cell-cycle arrest and DNA repair or to apoptosis. We show here that hematopoietic zinc finger (Hzf), a zinc-finger-containing p53 target gene, modulates p53 transactivation functions in an autoregulatory feedback loop. Hzf is induced by p53 and binds to its DNA-binding domain, resulting in preferential transactivation of proarrest p53 target genes over its proapoptotic target genes. Thus, p53 activation results in cell-cycle arrest in Hzf wild-type MEFs, while in Hzf(-/-) MEFs, apoptosis is induced. Exposure of Hzf null mice to ionizing radiation resulted in enhanced apoptosis in several organs, as compared to in wild-type mice. These findings provide novel insights into the regulation of p53 transactivation function and suggest that Hzf functions as a key player in regulating cell fate decisions in response to genotoxic stress.

Diseases/Pathways annotated by Medline MESH: Osteosarcoma, Prostatic Neoplasms
Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: RNF39 — TP53 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: UBC — RNF39 (physical association, affinity chromatography technology)
  • IRef Intact Interaction: ZNF385A — UBB (physical association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: ZNF385A — TP53 (physical association, anti bait coimmunoprecipitation)
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → HDAC2 (HDAC2) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → POU4F1 (POU4F1) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → BRG1 (SMARCA4) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → POU4F1 (POU4F1) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → BRG1 (SMARCA4) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → HZF (ZNF385A) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → p21CIP1 (CDKN1A) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → p53 (tetramer) complex (TP53) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → BRG1 (SMARCA4) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HZF (ZNF385A) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HZF (ZNF385A) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → HDAC2 (HDAC2) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → POU4F1 (POU4F1) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → BRG1 (SMARCA4) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → POU4F1 (POU4F1) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → BRG1 (SMARCA4) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → HZF (ZNF385A) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → p21CIP1 (CDKN1A) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → p53 (tetramer) complex (TP53) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → BRG1 (SMARCA4) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HZF (ZNF385A) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HZF (ZNF385A) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → SP1 (SP1) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → SLUG (SNAI2) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: SP1 (SP1) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: SP1 (SP1) → SLUG (SNAI2) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: p53 (tetramer) complex (TP53) → SLUG (SNAI2) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → HDAC2 (HDAC2) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → POU4F1 (POU4F1) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → BRG1 (SMARCA4) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → POU4F1 (POU4F1) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → BRG1 (SMARCA4) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → HZF (ZNF385A) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → p21CIP1 (CDKN1A) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HDAC2 (HDAC2) → p53 (tetramer) complex (TP53) (transcription, inhibits)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → BRG1 (SMARCA4) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: BRG1 (SMARCA4) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HZF (ZNF385A) → p21CIP1 (CDKN1A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: HZF (ZNF385A) → p53 (tetramer) complex (TP53) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: p53 (tetramer) complex (TP53) → 14-3-3 S (SFN) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: p53 (tetramer) complex (TP53) → HZF (ZNF385A) (transcription, activates)
    Evidence: mutant phenotype, reporter gene, physical interaction
In total, 48 gene pairs are associated to this article in curated databases