Gene interactions and pathways from curated databases and text-mining
J Biol Chem 2007, PMID: 17656363

Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes.

Garstka, Malgorzata; Borchert, Britta; Al-Balushi, Mohammed; Praveen, P V K; Kühl, Nicole; Majoul, Irina; Duden, Rainer; Springer, Sebastian

Prior to binding to a high affinity peptide and transporting it to the cell surface, major histocompatibility complex class I molecules are retained inside the cell by retention in the endoplasmic reticulum (ER), recycling through the ER-Golgi intermediate compartment and possibly the cis-Golgi, or both. Using fluorescence microscopy and a novel in vitro COPII (ER-to-ER-Golgi intermediate compartment) vesicle formation assay, we find that in both lymphocytes and fibroblasts that lack the functional transporter associated with antigen presentation, class I molecules exit the ER and reach the cis-Golgi. Intriguingly, in wild-type T1 lymphoma cells, peptide-occupied and peptide-receptive class I molecules are simultaneously exported from ER membranes with similar efficiencies. Our results suggest that binding of high affinity peptide and exit from the ER are not coupled, that the major histocompatibility complex class I quality control compartment extends into the Golgi apparatus under standard conditions, and that peptide loading onto class I molecules may occur in post-ER compartments.

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Text Mining Data

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Manually curated Databases

  • Reactome Reaction: HLA-F → TAP2 (reaction)
  • Reactome Reaction: HLA-G → PDIA3 (reaction)
  • Reactome Reaction: HLA-B → TAPBP (reaction)
  • Reactome Reaction: HLA-F → TAP1 (reaction)
  • Reactome Reaction: CALR → TAP1 (reaction)
  • Reactome Reaction: TAP1 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAPBP (reaction)
  • Reactome Reaction: CALR → PDIA3 (reaction)
  • Reactome Reaction: HLA-C → TAP1 (reaction)
  • Reactome Reaction: HLA-A → TAPBP (reaction)
  • Reactome Reaction: HLA-G → TAP2 (reaction)
  • Reactome Reaction: CALR → TAPBP (reaction)
  • Reactome Reaction: HLA-C → CALR (reaction)
  • Reactome Reaction: HLA-C → TAPBP (reaction)
  • Reactome Reaction: HLA-G → TAPBP (reaction)
  • Reactome Reaction: TAP2 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAP2 (reaction)
  • Reactome Reaction: HLA-A → CALR (reaction)
  • Reactome Reaction: B2M → TAP1 (reaction)
  • Reactome Reaction: HLA-F → PDIA3 (reaction)
  • Reactome Reaction: HLA-B → PDIA3 (reaction)
  • Reactome Reaction: CALR → HLA-G (reaction)
  • Reactome Reaction: CALR → TAP2 (reaction)
  • Reactome Reaction: HLA-A → TAP1 (reaction)
  • Reactome Reaction: HLA-C → TAP2 (reaction)
  • Reactome Reaction: B2M → PDIA3 (reaction)
  • Reactome Reaction: HLA-F → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAP1 (reaction)
  • Reactome Reaction: CALR → HLA-E (reaction)
  • Reactome Reaction: B2M → TAPBP (reaction)
  • Reactome Reaction: B2M → TAP2 (reaction)
  • Reactome Reaction: B2M → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAPBP (reaction)
  • Reactome Reaction: HLA-A → PDIA3 (reaction)
  • Reactome Reaction: CALR → HLA-F (reaction)
  • Reactome Reaction: HLA-A → TAP2 (reaction)
  • Reactome Reaction: HLA-E → PDIA3 (reaction)
  • Reactome Reaction: HLA-B → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAP1 (reaction)
  • Reactome Reaction: HLA-B → TAP1 (reaction)
  • Reactome Reaction: PDIA3 → TAP2 (reaction)
  • Reactome Reaction: HLA-B → TAP2 (reaction)
  • Reactome Reaction: HLA-C → PDIA3 (reaction)
  • Reactome Reaction: HLA-G → TAP1 (reaction)
In total, 44 gene pairs are associated to this article in curated databases