We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Biochim Biophys Acta 2006, PMID: 16844078

cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway.

Umenishi, Fuminori; Narikiyo, Takefumi; Vandewalle, Alain; Schrier, Robert W

The regulation of AVP-induced AQP2 expression was investigated in the present study. AVP administration induced AQP2 expression in a dose-dependent manner in association with an increase in intracellular cAMP concentration. PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression. However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression. These results therefore indicate that the effect of AVP stimulation to upregulate AQP2 expression involves a PKA-independent pathway.

Document information provided by NCBI PubMed

Text Mining Data

AQP2 → AVP: " The regulation of AVP induced AQP2 expression was investigated in the present study "

AQP2 ⊣ AVP: " PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression "

AQP2 → PKA: " PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression "

PKA → AVP: " PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression "

AQP2 ⊣ AVP: " However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression "

ERK → AVP: " However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression "

AQP2 → ERK: " However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression "

Manually curated Databases

No curated data.