Gene interactions and pathways from curated databases and text-mining
J Biol Chem 2005, PMID: 16230350

A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.

Jin, Jingji; Cai, Yong; Yao, Tingting; Gottschalk, Aaron J; Florens, Laurence; Swanson, Selene K; Gutiérrez, José L; Coleman, Michael K; Workman, Jerry L; Mushegian, Arcady; Washburn, Michael P; Conaway, Ronald C; Conaway, Joan Weliky

The mammalian Tip49a and Tip49b proteins belong to an evolutionarily conserved family of AAA+ ATPases. In Saccharomyces cerevisiae, orthologs of Tip49a and Tip49b, called Rvb1 and Rvb2, respectively, are subunits of two distinct ATP-dependent chromatin remodeling complexes, SWR1 and INO80. We recently demonstrated that the mammalian Tip49a and Tip49b proteins are integral subunits of a chromatin remodeling complex bearing striking similarities to the S. cerevisiae SWR1 complex (Cai, Y., Jin, J., Florens, L., Swanson, S. K., Kusch, T., Li, B., Workman, J. L., Washburn, M. P., Conaway, R. C., and Conaway, J. W. (2005) J. Biol. Chem. 280, 13665-13670). In this report, we identify a new mammalian Tip49a- and Tip49b-containing ATP-dependent chromatin remodeling complex, which includes orthologs of 8 of the 15 subunits of the S. cerevisiae INO80 chromatin remodeling complex as well as at least five additional subunits unique to the human INO80 (hINO80) complex. Finally, we demonstrate that, similar to the yeast INO80 complex, the hINO80 complex exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

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Text Mining Data

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Manually curated Databases

  • MIPS CORUM INO80 chromatin remodeling complex: INO80 chromatin remodeling complex complex (ACTL6A-ACTR5-ACTR8-INO80C-INO80E-INO80D-INO80-MCRS1-NFRKB-RUVBL1-RUVBL2-TCF3-INO80B)
  • IRef Corum Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation)
  • IRef Hprd Interaction: Complex of 53 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 337 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 337 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 1457 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 55 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 511 proteins (in vivo)
  • IRef Hprd Interaction: MRGBP — MEAF6 (in vitro)
  • IRef Hprd Interaction: MRGBP — MORF4L2 (in vitro)
  • IRef Hprd Interaction: Complex of 545 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 161 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 129 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 19 proteins (in vivo)
  • IRef Intact Interaction: Complex of 79 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 35 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 26 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 19 proteins (association, anti bait coimmunoprecipitation)
In total, 514 gene pairs are associated to this article in curated databases