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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Science 2004, PMID: 15353805

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.

Li, Lin; Thomas, Ranny Mathew; Suzuki, Hidetaka; De Brabander, Jef K; Wang, Xiaodong; Harran, Patrick G

We describe the synthesis and properties of a small molecule mimic of Smac, a pro-apoptotic protein that functions by relieving inhibitor-of-apoptosis protein (IAP)-mediated suppression of caspase activity. The compound binds to X chromosome- encoded IAP (XIAP), cellular IAP 1 (cIAP-1), and cellular IAP 2 (cIAP-2) and synergizes with both tumor necrosis factor alpha (TNFalpha) and TNF-related apoptosis-inducing ligand (TRAIL) to potently induce caspase activation and apoptosis in human cancer cells. The molecule has allowed a temporal, unbiased evaluation of the roles that IAP proteins play during signaling from TRAIL and TNF receptors. The compound is also a lead structure for the development of IAP antagonists potentially useful as therapy for cancer and inflammatory diseases.

Diseases/Pathways annotated by Medline MESH: Glioblastoma
Document information provided by NCBI PubMed

Text Mining Data

caspase ⊣ inhibitor-of-apoptosis protein (IAP): " We describe the synthesis and properties of a small molecule mimic of Smac, a pro-apoptotic protein that functions by relieving inhibitor-of-apoptosis protein (IAP) mediated suppression of caspase activity "

Manually curated Databases

No curated data.