Gene interactions and pathways from curated databases and text-mining
Proc Natl Acad Sci U S A 2004, PMID: 15286279

Tapasin enhances MHC class I peptide presentation according to peptide half-life.

Howarth, Mark; Williams, Anthony; Tolstrup, Anne B; Elliott, Tim

Understanding how peptides are selected for presentation by MHC class I is crucial to vaccination strategies based on cytotoxic T lymphocyte priming. We have studied this selection of the MHC class I peptide repertoire in terms of the presentation of a series of individual peptides with a wide range of binding to MHC class I. This series was expressed as minigenes, and the presentation of each peptide variant was determined with the same MHC class I peptide-specific antibody. In wild-type cells, the hierarchy of presentation followed peptide half-life. This hierarchy broke down in cells lacking tapasin but not in cells lacking calreticulin or in cells lacking transporter associated with antigen processing-associated ERp57. We demonstrate a key role for tapasin in shaping the MHC class I peptide repertoire, as enhancement of presentation in the presence of tapasin correlated with peptide half-life.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: HLA-F → TAP2 (reaction)
  • Reactome Reaction: HLA-G → TAP1 (indirect_complex)
  • Reactome Reaction: CALR → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-B → TAPBP (reaction)
  • Reactome Reaction: HLA-F → TAP1 (reaction)
  • Reactome Reaction: HLA-F → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-E → TAP1 (indirect_complex)
  • Reactome Reaction: B2M → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-F → TAP1 (indirect_complex)
  • Reactome Reaction: CALR → TAP1 (reaction)
  • Reactome Reaction: TAP1 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAPBP (reaction)
  • Reactome Reaction: B2M → CALR (indirect_complex)
  • Reactome Reaction: CALR → PDIA3 (reaction)
  • Reactome Reaction: HLA-C → TAP1 (reaction)
  • Reactome Reaction: HLA-A → TAPBP (reaction)
  • Reactome Reaction: HLA-G → TAP2 (reaction)
  • Reactome Reaction: CALR → TAPBP (reaction)
  • Reactome Reaction: TAP1 → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-C → CALR (reaction)
  • Reactome Reaction: HLA-B → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-B → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-C → TAPBP (reaction)
  • Reactome Reaction: HLA-B → TAPBP (indirect_complex)
  • Reactome Reaction: PDIA3 → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-G → TAPBP (reaction)
  • Reactome Reaction: TAP2 → TAPBP (reaction)
  • Reactome Reaction: HLA-E → TAP2 (reaction)
  • Reactome Reaction: HLA-A → CALR (reaction)
  • Reactome Reaction: HLA-A → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-A → CALR (indirect_complex)
  • Reactome Reaction: B2M → TAP1 (reaction)
  • Reactome Reaction: B2M → TAPBP (indirect_complex)
  • Reactome Reaction: CALR → TAPBP (direct_complex)
  • Reactome Reaction: CALR → HLA-G (reaction)
  • Reactome Reaction: CALR → TAP2 (reaction)
  • Reactome Reaction: HLA-A → TAP1 (reaction)
  • Reactome Reaction: B2M → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-C → TAP2 (reaction)
  • Reactome Reaction: CALR → PDIA3 (indirect_complex)
  • Reactome Reaction: HLA-C → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-F → TAPBP (reaction)
  • Reactome Reaction: CALR → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-E → TAP1 (reaction)
  • Reactome Reaction: PDIA3 → TAP2 (indirect_complex)
  • Reactome Reaction: CALR → HLA-E (indirect_complex)
  • Reactome Reaction: CALR → HLA-E (reaction)
  • Reactome Reaction: B2M → TAPBP (reaction)
  • Reactome Reaction: HLA-C → CALR (indirect_complex)
  • Reactome Reaction: B2M → TAP2 (reaction)
  • Reactome Reaction: HLA-F → TAP2 (indirect_complex)
  • Reactome Reaction: CALR → HLA-F (indirect_complex)
  • Reactome Reaction: HLA-E → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-G → TAP2 (indirect_complex)
  • Reactome Reaction: B2M → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAPBP (reaction)
  • Reactome Reaction: HLA-A → TAP1 (indirect_complex)
  • Reactome Reaction: CALR → HLA-F (reaction)
  • Reactome Reaction: HLA-C → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-A → TAP2 (reaction)
  • Reactome Reaction: HLA-C → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-A → TAP2 (indirect_complex)
  • Reactome Reaction: TAP2 → TAPBP (indirect_complex)
  • Reactome Reaction: HLA-B → CALR (reaction)
  • Reactome Reaction: PDIA3 → TAP1 (indirect_complex)
  • Reactome Reaction: HLA-E → TAP2 (indirect_complex)
  • Reactome Reaction: HLA-G → TAPBP (indirect_complex)
  • Reactome Reaction: PDIA3 → TAP1 (reaction)
  • Reactome Reaction: HLA-B → TAP1 (reaction)
  • Reactome Reaction: PDIA3 → TAP2 (reaction)
  • Reactome Reaction: HLA-B → TAP2 (reaction)
  • Reactome Reaction: CALR → HLA-G (indirect_complex)
  • Reactome Reaction: HLA-B → CALR (indirect_complex)
  • Reactome Reaction: HLA-G → TAP1 (reaction)
In total, 37 gene pairs are associated to this article in curated databases