Gene interactions and pathways from curated databases and text-mining
Proc Natl Acad Sci U S A 1992, PMID: 1376928

Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.

Coggeshall, K M; McHugh, J C; Altman, A

The triggering of T- or B-cell antigen-specific receptors is accompanied by rapid tyrosine phosphorylation of distinct cellular substrates, one of which is the gamma 1 isoform of inositol phospholipid-specific phospholipase C (PLC-gamma 1). This phosphorylation event, mediated by a putative protein tyrosine kinase coupled to the antigen receptor, probably stimulates the enzymatic activity of PLC-gamma 1, thereby promoting inositol phospholipid hydrolysis and other downstream signal transduction events. Recently, another ubiquitously expressed PLC isoform, PLC-gamma 2 (which shares 50.2% amino acid homology with PLC-gamma 1), has been identified. PLC-gamma 2-specific antibodies were used to evaluate the distribution and potential signaling role of this isoform in lymphocytes. Here, we report that, in contrast to T lymphocytes that express predominantly PLC-gamma 1, the major isoform expressed in murine and human resting B cells is PLC-gamma 2. Among B-cell tumor lines, all five murine B-lymphoma lines tested and one of six human B-lymphoblastoid cell lines also expressed predominantly PLC-gamma 2. However, three other human lines preferentially expressed PLC-gamma 1, and two others displayed similar levels of the two PLC-gamma isoforms. Furthermore, the triggering of B-cell surface immunoglobulin by anti-receptor antibodies was accompanied by a rapid tyrosine phosphorylation of PLC-gamma 2, which peaked after 5 min of stimulation. Conversely, and in agreement with recent reports, triggering of the T-cell antigen receptor complex led to the predominant phosphorylation of PLC-gamma 1 on tyrosine. These findings identify PLC-gamma 2 as a substrate for a B-cell putative protein tyrosine kinase coupled to the antigen receptor and suggest that its tyrosine phosphorylation constitutes a critical and early event in B-cell activation and, furthermore, that PLC-gamma 1 and PLC-gamma 2 may participate in similar but distinct signal transduction pathways in lymphocytes.

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Manually curated Databases

  • Reactome Reaction: CD79B → NCK1 (indirect_complex)
  • Reactome Reaction: SYK → SHC1 (indirect_complex)
  • Reactome Reaction: IGHM → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → CBLB (indirect_complex)
  • Reactome Reaction: CD79B → DAPP1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: PIK3CD → PIK3AP1 (indirect_complex)
  • Reactome Reaction: BTK → IGHM (indirect_complex)
  • Reactome Reaction: IGKV4-1 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG1 → BLNK (indirect_complex)
  • Reactome Reaction: IGKV1-5 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGHM → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → IGKV1-5 (indirect_complex)
  • Reactome Reaction: PIK3CD → VAV1 (indirect_complex)
  • Reactome Reaction: PIK3R1 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → BLNK (indirect_complex)
  • Reactome Reaction: SOS1 → VAV1 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC3 (indirect_complex)
  • Reactome Reaction: SYK → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → SHC1 (direct_complex)
  • Reactome Reaction: GRB2 → DAPP1 (indirect_complex)
  • Reactome Reaction: SYK → NCK1 (indirect_complex)
  • Reactome Reaction: BTK → SYK (indirect_complex)
  • Reactome Reaction: CD79A → SHC1 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC6 (indirect_complex)
  • Reactome Reaction: NCK1 → PLCG2 (indirect_complex)
  • Reactome Reaction: PIK3R1 → PIK3AP1 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC6 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → IGKV4-1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → PLCG2 (indirect_complex)
  • Reactome Reaction: CD79A → PLCG2 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC3 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGHD → VAV1 (indirect_complex)
  • Reactome Reaction: DAPP1 → SHC1 (indirect_complex)
  • Reactome Reaction: SYK → VAV1 (indirect_complex)
  • Reactome Reaction: SHC1 → BLNK (indirect_complex)
  • Reactome Reaction: CD79B → VAV1 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC3 (indirect_complex)
  • Reactome Reaction: BTK → IGLC1 (indirect_complex)
  • Reactome Reaction: IGKC → PLCG1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → IGKC (indirect_complex)
  • Reactome Reaction: BTK → NCK1 (indirect_complex)
  • Reactome Reaction: NCK1 → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC7 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC6 (indirect_complex)
  • Reactome Reaction: PLCG1 → VAV1 (indirect_complex)
  • Reactome Reaction: SHC1 → CBLB (indirect_complex)
  • Reactome Reaction: VAV1 → BLNK (indirect_complex)
  • Reactome Reaction: GRB2 → VAV1 (indirect_complex)
  • Reactome Reaction: CBL → PLCG2 (indirect_complex)
  • Reactome Reaction: PLCG1 → DAPP1 (indirect_complex)
  • Reactome Reaction: BTK → SHC1 (indirect_complex)
  • Reactome Reaction: GRB2 → PIK3R1 (indirect_complex)
  • Reactome Reaction: GRB2 → SHC1 (indirect_complex)
  • Reactome Reaction: IGKC → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → SOS1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → CBL (indirect_complex)
  • Reactome Reaction: GRB2 → NCK1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → NCK1 (indirect_complex)
  • Reactome Reaction: PLCG1 → SOS1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC2 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC2 (indirect_complex)
  • Reactome Reaction: NCK1 → VAV1 (direct_complex)
  • Reactome Reaction: PLCG2 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGHD → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → CD79B (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC1 (indirect_complex)
  • Reactome Reaction: PLCG1 → CBLB (indirect_complex)
  • Reactome Reaction: BTK → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → BLNK (indirect_complex)
  • Reactome Reaction: PLCG2 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SOS1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → PLCG1 (indirect_complex)
  • Reactome Reaction: IGHM → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC6 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC7 (indirect_complex)
  • Reactome Reaction: IGHM → NCK1 (indirect_complex)
  • Reactome Reaction: CD79A → DAPP1 (indirect_complex)
  • Reactome Reaction: GRB2 → PIK3CD (indirect_complex)
  • Reactome Reaction: IGHD → NCK1 (indirect_complex)
  • Reactome Reaction: DAPP1 → BLNK (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → PLCG2 (indirect_complex)
  • Reactome Reaction: DAPP1 → CBLB (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → CD79A (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC2 (indirect_complex)
  • Reactome Reaction: IGHD → SHC1 (indirect_complex)
  • Reactome Reaction: IGKC → SHC1 (indirect_complex)
  • Reactome Reaction: SOS1 → DAPP1 (indirect_complex)
  • Reactome Reaction: VAV1 → CBLB (indirect_complex)
  • Reactome Reaction: CD19 → PIK3R1 (indirect_complex)
  • Reactome Reaction: CD19 → PIK3CD (indirect_complex)
  • Reactome Reaction: GRB2 → VAV1 (direct_complex)
  • Reactome Reaction: PLCG2 → IGLC7 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGHD → PLCG1 (indirect_complex)
  • Reactome Reaction: PLCG2 → CBLB (indirect_complex)
  • Reactome Reaction: IGKC → PLCG2 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → NCK1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → PLCG1 (indirect_complex)
  • Reactome Reaction: CD19 → GRB2 (direct_complex)
  • Reactome Reaction: CBL → DAPP1 (indirect_complex)
  • Reactome Reaction: SYK → PLCG1 (indirect_complex)
  • Reactome Reaction: CD79A → PLCG1 (indirect_complex)
  • Reactome Reaction: CD79A → VAV1 (indirect_complex)
  • Reactome Reaction: NCK1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: PLCG1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC7 (indirect_complex)
  • Reactome Reaction: SYK → PLCG2 (indirect_complex)
  • Reactome Reaction: BTK → VAV1 (indirect_complex)
  • Reactome Reaction: SOS1 → SHC1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → VAV1 (indirect_complex)
  • Reactome Reaction: BTK → CBLB (indirect_complex)
  • Reactome Reaction: BTK → GRB2 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC6 (indirect_complex)
  • Reactome Reaction: CBL → VAV1 (indirect_complex)
  • Reactome Reaction: IGHD → PLCG2 (indirect_complex)
  • Reactome Reaction: NCK1 → BLNK (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC1 (indirect_complex)
  • Reactome Reaction: CBL → NCK1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC3 (indirect_complex)
  • Reactome Reaction: VAV1 → SHC1 (direct_complex)
  • Reactome Reaction: IGHM → PLCG2 (indirect_complex)
  • Reactome Reaction: CBL → SHC1 (indirect_complex)
  • Reactome Reaction: SH3KBP1 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGKC → VAV1 (indirect_complex)
  • Reactome Reaction: CD79A → NCK1 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC2 (indirect_complex)
  • Reactome Reaction: NCK1 → DAPP1 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC3 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC6 (indirect_complex)
  • Reactome Reaction: BTK → SH3KBP1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC6 (indirect_complex)
  • Reactome Reaction: IGKC → NCK1 (indirect_complex)
  • Reactome Reaction: CD79B → PLCG1 (indirect_complex)
  • Reactome Reaction: VAV1 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → SOS1 (indirect_complex)
  • Reactome Reaction: CBL → PLCG1 (indirect_complex)
  • Reactome Reaction: CD19 → VAV1 (direct_complex)
  • Reactome Reaction: NCK1 → IGLC3 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC3 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → DAPP1 (indirect_complex)
  • Reactome Reaction: CD79B → PLCG2 (indirect_complex)
  • Reactome Reaction: PLCG1 → SHC1 (indirect_complex)
  • Reactome Reaction: IGHM → SHC1 (indirect_complex)
  • Reactome Reaction: VAV1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → IGHD (indirect_complex)
  • Reactome Reaction: CD79B → SHC1 (indirect_complex)
  • Reactome Reaction: GRB2 → PLCG1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → PLCG2 (indirect_complex)
  • Reactome Reaction: GRB2 → PLCG2 (indirect_complex)
  • Reactome Reaction: SH3KBP1 → SHC1 (indirect_complex)
In total, 163 gene pairs are associated to this article in curated databases