We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
J Biol Chem 2003, PMID: 12963728

Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

Cai, Yong; Jin, Jingji; Tomomori-Sato, Chieri; Sato, Shigeo; Sorokina, Irina; Parmely, Tari J; Conaway, Ronald C; Conaway, Joan Weliky

The mammalian ATM/PI 3-kinase-related TRRAP protein was previously found to be a component of a multi-protein histone acetyltransferase (HAT) complex containing the HAT TIP60. In this report, we identify a previously uncharacterized protein encoded by the FLJ10914 ORF, which we designate MRGBP, as a new component of the TRRAP/TIP60 HAT complex. In addition, through purification of MRGBP and its associated proteins from HeLa cell nuclear extracts, we identify the thyroid receptor coactivating protein (TRCp120), DMAP1, and the related MRG15 and MRGX proteins as MRGBP-associating proteins, and we present biochemical evidence that they are previously unrecognized components of the TRRAP/TIP60 HAT complex. Taken together, our findings shed new light on the structure and function of the mammalian TRRAP/TIP60 histone acetyltransferase complex.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: MRGBP — ING1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — TRRAP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — EPC1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — KAT5 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSPA4 — MRGBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — MEAF6 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — BRD8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — MORF4L1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RUVBL1 — MRGBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — YEATS4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — ACTL6A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — MORF4L2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — DMAP1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RSL1D1 — MRGBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRGBP — RUVBL2 (physical association, affinity chromatography technology)
  • MIPS CORUM NuA4/Tip60 HAT complex: NuA4/Tip60 HAT complex complex (ACTL6A-BRD8-MEAF6-DMAP1-EP400-EPC1-KAT5-ING3-MORF4L1-MORF4L2-MRGBP-RUVBL1-RUVBL2-TRRAP-YEATS4)
  • IRef Corum Interaction: Complex of 16 proteins (association, affinity chromatography technology)
  • IRef Hprd Interaction: MRGBP — ING1 (in vitro)
  • IRef Hprd Interaction: MRGBP — TRRAP (in vitro)
  • IRef Hprd Interaction: BRD8 — TRRAP (in vivo)
  • IRef Hprd Interaction: BRD8 — TRRAP (in vitro)
  • IRef Hprd Interaction: Complex of 325 proteins (in vivo)
  • IRef Hprd Interaction: MRGBP — MEAF6 (in vitro)
  • IRef Hprd Interaction: BRD8 — MRGBP (in vitro)
  • IRef Hprd Interaction: MRGBP — MORF4L1 (in vitro)
  • IRef Hprd Interaction: RUVBL1 — MRGBP (in vitro)
  • IRef Hprd Interaction: MRGBP — YEATS4 (in vitro)
  • IRef Hprd Interaction: MRGBP — ACTL6A (in vitro)
  • IRef Hprd Interaction: MRGBP — MORF4L2 (in vitro)
  • IRef Hprd Interaction: MRGBP — DMAP1 (in vitro)
  • IRef Hprd Interaction: MRGBP — TUBB (in vitro)
  • IRef Hprd Interaction: MRGBP — ACTB (in vitro)
  • IRef Intact Interaction: Complex of 18 proteins (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of MRGBP-TRRAP-DMAP1-KAT5-KAT5-TRRAP-MRGBP-DMAP1 (physical association, biochemical)
  • IRef Intact Interaction: Complex of MRGBP-EP400-MORF4L2-MORF4L1-BRD8-TRRAP (physical association, biochemical)
  • IRef Intact Interaction: Complex of 11 proteins (physical association, molecular sieving)
In total, 200 gene pairs are associated to this article in curated databases