ID:ZXDC_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein ZXDC; AltName: Full=ZXD-like zinc finger protein; FUNCTION: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. SUBUNIT: Self-associates. Interacts with ZXDA and CIITA. INTERACTION: P33076:CIITA; NbExp=6; IntAct=EBI-1538838, EBI-1538819; P98168:ZXDA; NbExp=5; IntAct=EBI-1538838, EBI-1538980; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen. SIMILARITY: Belongs to the ZXD family. SIMILARITY: Contains 10 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAC03805.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q2QGD7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0030275 LRR domain binding GO:0046872 metal ion binding GO:0070742 C2H2 zinc finger domain binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045893 positive regulation of transcription, DNA-templated
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
