Human Gene ZSCAN1 (ENST00000282326.6_4) from GENCODE V47lift37
  Description: zinc finger and SCAN domain containing 1 (from RefSeq NM_182572.4)
Gencode Transcript: ENST00000282326.6_4
Gencode Gene: ENSG00000152467.10_8
Transcript (Including UTRs)
   Position: hg19 chr19:58,545,393-58,565,999 Size: 20,607 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr19:58,549,205-58,565,419 Size: 16,215 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:58,545,393-58,565,999)mRNA (may differ from genome)Protein (408 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZSCA1_HUMAN
DESCRIPTION: RecName: Full=Zinc finger and SCAN domain-containing protein 1;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 3 C2H2-type zinc fingers.
SIMILARITY: Contains 1 SCAN box domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZSCAN1
Diseases sorted by gene-association score: arrhythmogenic right ventricular dysplasia 1 (2)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.55 RPKM in Pituitary
Total median expression: 33.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.40288-0.442 Picture PostScript Text
3' UTR -230.40580-0.397 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF02023 - SCAN domain

SCOP Domains:
47353 - Retrovirus capsid dimerization domain-like
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on Q8NBB4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC107729 - Homo sapiens zinc finger and SCAN domain containing 1, mRNA (cDNA clone IMAGE:4688272), complete cds.
AK091098 - Homo sapiens cDNA FLJ33779 fis, clone BRSSN2006644, weakly similar to ZINC FINGER PROTEIN 202.
AX746779 - Sequence 304 from Patent EP1308459.
BC048099 - Homo sapiens zinc finger and SCAN domain containing 1, mRNA (cDNA clone IMAGE:4798078), complete cds.
AY280370 - Homo sapiens zinc finger protein mRNA, complete cds.
JD137612 - Sequence 118636 from Patent EP1572962.
JD077226 - Sequence 58250 from Patent EP1572962.
CU690548 - Synthetic construct Homo sapiens gateway clone IMAGE:100022693 5' read ZSCAN1 mRNA.
KJ904129 - Synthetic construct Homo sapiens clone ccsbBroadEn_13523 ZSCAN1 gene, encodes complete protein.
JD251226 - Sequence 232250 from Patent EP1572962.
JD193178 - Sequence 174202 from Patent EP1572962.
JD309664 - Sequence 290688 from Patent EP1572962.
JD068972 - Sequence 49996 from Patent EP1572962.
JD114967 - Sequence 95991 from Patent EP1572962.
JD165929 - Sequence 146953 from Patent EP1572962.
JD174051 - Sequence 155075 from Patent EP1572962.
JD209688 - Sequence 190712 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000282326.1, ENST00000282326.2, ENST00000282326.3, ENST00000282326.4, ENST00000282326.5, NM_182572, Q3B798, Q6WLH8, Q86WS8, Q8NBB4, uc317jzd.1, uc317jzd.2, ZSCA1_HUMAN
UCSC ID: ENST00000282326.6_4
RefSeq Accession: NM_182572.4
Protein: Q8NBB4 (aka ZSCA1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.