Human Gene ZNF814 (ENST00000435989.7_7) from GENCODE V47lift37
  Description: zinc finger protein 814 (from RefSeq NM_001144989.2)
Gencode Transcript: ENST00000435989.7_7
Gencode Gene: ENSG00000204514.11_12
Transcript (Including UTRs)
   Position: hg19 chr19:58,380,749-58,400,405 Size: 19,657 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:58,384,190-58,400,170 Size: 15,981 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:58,380,749-58,400,405)mRNA (may differ from genome)Protein (855 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN814_HUMAN
DESCRIPTION: RecName: Full=Putative uncharacterized zinc finger protein 814; AltName: Full=Putative zinc finger protein LOC730051;
SIMILARITY: Contains 23 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.15 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 95.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.50235-0.364 Picture PostScript Text
3' UTR -1064.703441-0.309 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on B7Z6K7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045892 negative regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BC056684 - Homo sapiens cDNA clone IMAGE:6653606, partial cds.
AK022663 - Homo sapiens cDNA FLJ12601 fis, clone NT2RM4001414.
AF086563 - Homo sapiens full length insert cDNA clone ZE16C11.
AK091350 - Homo sapiens cDNA FLJ34031 fis, clone FCBBF2003895.
AX746928 - Sequence 453 from Patent EP1308459.
JD242698 - Sequence 223722 from Patent EP1572962.
JD293437 - Sequence 274461 from Patent EP1572962.
JD300765 - Sequence 281789 from Patent EP1572962.
JD433350 - Sequence 414374 from Patent EP1572962.
JD565053 - Sequence 546077 from Patent EP1572962.
JD379576 - Sequence 360600 from Patent EP1572962.
JD094048 - Sequence 75072 from Patent EP1572962.
JD379575 - Sequence 360599 from Patent EP1572962.
JD513889 - Sequence 494913 from Patent EP1572962.
JD513890 - Sequence 494914 from Patent EP1572962.
JD414342 - Sequence 395366 from Patent EP1572962.
JD414343 - Sequence 395367 from Patent EP1572962.
JD384741 - Sequence 365765 from Patent EP1572962.
JD252599 - Sequence 233623 from Patent EP1572962.
JD293487 - Sequence 274511 from Patent EP1572962.
AK300483 - Homo sapiens cDNA FLJ61598 complete cds, moderately similar to Zinc finger protein 418.
JD314815 - Sequence 295839 from Patent EP1572962.
JD314815 - Sequence 295839 from Patent EP1572962.
JD314815 - Sequence 295839 from Patent EP1572962.
JD314814 - Sequence 295838 from Patent EP1572962.
BC026064 - Homo sapiens cDNA clone IMAGE:3945154, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NF35, B7Z6K7, ENST00000435989.1, ENST00000435989.2, ENST00000435989.3, ENST00000435989.4, ENST00000435989.5, ENST00000435989.6, NM_001144989, uc320ejw.1, uc320ejw.2, ZN814_HUMAN
UCSC ID: ENST00000435989.7_7
RefSeq Accession: NM_001144989.2
Protein: B7Z6K7 (aka ZN814_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.