Human Gene ZNF784 (ENST00000325351.5_6) from GENCODE V47lift37
  Description: zinc finger protein 784 (from RefSeq NM_203374.2)
Gencode Transcript: ENST00000325351.5_6
Gencode Gene: ENSG00000179922.6_8
Transcript (Including UTRs)
   Position: hg19 chr19:56,132,107-56,135,932 Size: 3,826 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr19:56,133,117-56,135,927 Size: 2,811 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:56,132,107-56,135,932)mRNA (may differ from genome)Protein (323 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN784_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 784;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 6 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C014024 2,4,5,2',4',5'-hexachlorobiphenyl
  • C023035 3,4,5,3',4'-pentachlorobiphenyl
  • C006780 bisphenol A
  • C023036 perfluorooctanoic acid
  • C517826 tetrabrominated diphenyl ether 47

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.67 RPKM in Muscle - Skeletal
Total median expression: 274.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -406.601010-0.403 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12171 - Zinc-finger double-stranded RNA-binding
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
82919 - Zn-finger domain of Sec23/24
57783 - Zinc beta-ribbon

ModBase Predicted Comparative 3D Structure on Q8NCA9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF207497 - JP 2014500723-A/15000: Polycomb-Associated Non-Coding RNAs.
LF207498 - JP 2014500723-A/15001: Polycomb-Associated Non-Coding RNAs.
AF086055 - Homo sapiens full length insert cDNA clone YY87C09.
AK074859 - Homo sapiens cDNA FLJ90378 fis, clone NT2RP2004847, weakly similar to ZINC FINGER PROTEIN 135.
BC065822 - Homo sapiens zinc finger protein 784, mRNA (cDNA clone MGC:75238 IMAGE:6185645), complete cds.
JD346300 - Sequence 327324 from Patent EP1572962.
JD220755 - Sequence 201779 from Patent EP1572962.
JD159508 - Sequence 140532 from Patent EP1572962.
JD490251 - Sequence 471275 from Patent EP1572962.
JD520892 - Sequence 501916 from Patent EP1572962.
JD085922 - Sequence 66946 from Patent EP1572962.
AK309967 - Homo sapiens cDNA, FLJ17009.
JD367741 - Sequence 348765 from Patent EP1572962.
JD321522 - Sequence 302546 from Patent EP1572962.
JD411631 - Sequence 392655 from Patent EP1572962.
JD516545 - Sequence 497569 from Patent EP1572962.
JD185769 - Sequence 166793 from Patent EP1572962.
JD050493 - Sequence 31517 from Patent EP1572962.
JD100479 - Sequence 81503 from Patent EP1572962.
JD051320 - Sequence 32344 from Patent EP1572962.
JD324904 - Sequence 305928 from Patent EP1572962.
JD229099 - Sequence 210123 from Patent EP1572962.
JD243530 - Sequence 224554 from Patent EP1572962.
JD146493 - Sequence 127517 from Patent EP1572962.
JD532409 - Sequence 513433 from Patent EP1572962.
JD549058 - Sequence 530082 from Patent EP1572962.
JD332651 - Sequence 313675 from Patent EP1572962.
JD215282 - Sequence 196306 from Patent EP1572962.
JD222599 - Sequence 203623 from Patent EP1572962.
JD495097 - Sequence 476121 from Patent EP1572962.
KJ895607 - Synthetic construct Homo sapiens clone ccsbBroadEn_05001 ZNF784 gene, encodes complete protein.
JD261132 - Sequence 242156 from Patent EP1572962.
MA443074 - JP 2018138019-A/15000: Polycomb-Associated Non-Coding RNAs.
MA443075 - JP 2018138019-A/15001: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000325351.1, ENST00000325351.2, ENST00000325351.3, ENST00000325351.4, NM_203374, Q8NCA9, uc317rwb.1, uc317rwb.2, ZN784_HUMAN
UCSC ID: ENST00000325351.5_6
RefSeq Accession: NM_203374.2
Protein: Q8NCA9 (aka ZN784_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.