Human Gene ZNF764 (ENST00000395091.3_8) from GENCODE V47lift37

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Description: zinc finger protein 764, transcript variant 2 (from RefSeq NM_001172679.2)
Gencode Transcript: ENST00000395091.3_8
Gencode Gene: ENSG00000169951.10_13
Transcript (Including UTRs)
Position: hg19 chr16:30,565,085-30,569,695 Size: 4,611 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr16:30,566,515-30,569,503 Size: 2,989 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr16:30,565,085-30,569,695)			mRNA (may differ from genome)		Protein (407 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZN764_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 764; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 7 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ZNF764 Diseases sorted by gene-association score: thyroid hormone resistance (11)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D005557 Formaldehyde C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine D019287 Zinc Sulfate C018021 cobaltous chloride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.16 RPKM in Testis Total median expression: 173.06 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-78.20	192	-0.407	Picture	PostScript	Text
3' UTR	-458.60	1430	-0.321	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
54862 - 4Fe-4S ferredoxins
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q96H86


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	BC000016 - Homo sapiens zinc finger protein 764, mRNA (cDNA clone IMAGE:3508146), partial cds. BC008821 - Homo sapiens zinc finger protein 764, mRNA (cDNA clone MGC:13138 IMAGE:4130947), complete cds. JD045760 - Sequence 26784 from Patent EP1572962. JD206451 - Sequence 187475 from Patent EP1572962. JD540263 - Sequence 521287 from Patent EP1572962. JD324566 - Sequence 305590 from Patent EP1572962. JD147093 - Sequence 128117 from Patent EP1572962. JD345203 - Sequence 326227 from Patent EP1572962. JD086752 - Sequence 67776 from Patent EP1572962. JD348765 - Sequence 329789 from Patent EP1572962. JD490446 - Sequence 471470 from Patent EP1572962. JD206683 - Sequence 187707 from Patent EP1572962. AK093992 - Homo sapiens cDNA FLJ36673 fis, clone UTERU2004163, weakly similar to Zinc finger protein 688. AX748400 - Sequence 1925 from Patent EP1308459. JD518448 - Sequence 499472 from Patent EP1572962. JD351295 - Sequence 332319 from Patent EP1572962. JD318041 - Sequence 299065 from Patent EP1572962. JD369221 - Sequence 350245 from Patent EP1572962. JD369220 - Sequence 350244 from Patent EP1572962. JD293311 - Sequence 274335 from Patent EP1572962. JD229137 - Sequence 210161 from Patent EP1572962. JD281690 - Sequence 262714 from Patent EP1572962. JD232944 - Sequence 213968 from Patent EP1572962. JD549103 - Sequence 530127 from Patent EP1572962. DQ588234 - Homo sapiens piRNA piR-55346, complete sequence. JD341407 - Sequence 322431 from Patent EP1572962. JD505999 - Sequence 487023 from Patent EP1572962. JD285553 - Sequence 266577 from Patent EP1572962. JD163846 - Sequence 144870 from Patent EP1572962. JD213691 - Sequence 194715 from Patent EP1572962. JD521766 - Sequence 502790 from Patent EP1572962. JD245798 - Sequence 226822 from Patent EP1572962. JD505650 - Sequence 486674 from Patent EP1572962. JD536105 - Sequence 517129 from Patent EP1572962. JD059811 - Sequence 40835 from Patent EP1572962. JD196790 - Sequence 177814 from Patent EP1572962. JD069562 - Sequence 50586 from Patent EP1572962. JD541342 - Sequence 522366 from Patent EP1572962. JD072966 - Sequence 53990 from Patent EP1572962. JD265963 - Sequence 246987 from Patent EP1572962. JD072741 - Sequence 53765 from Patent EP1572962. JD558162 - Sequence 539186 from Patent EP1572962. JD269808 - Sequence 250832 from Patent EP1572962. JD323584 - Sequence 304608 from Patent EP1572962. JD165488 - Sequence 146512 from Patent EP1572962. JD446492 - Sequence 427516 from Patent EP1572962. JD407307 - Sequence 388331 from Patent EP1572962. JD057821 - Sequence 38845 from Patent EP1572962. JD231505 - Sequence 212529 from Patent EP1572962. JD331700 - Sequence 312724 from Patent EP1572962. JF432713 - Synthetic construct Homo sapiens clone IMAGE:100073953 zinc finger protein 764 (ZNF764) gene, encodes complete protein. KJ899950 - Synthetic construct Homo sapiens clone ccsbBroadEn_09344 ZNF764 gene, encodes complete protein. EU446557 - Synthetic construct Homo sapiens clone IMAGE:100070243; IMAGE:100011766; FLH257354.01L zinc finger protein 764 (ZNF764) gene, encodes complete protein. DQ574270 - Homo sapiens piRNA piR-42382, complete sequence. JD382979 - Sequence 364003 from Patent EP1572962. DQ577011 - Homo sapiens piRNA piR-45123, complete sequence. JD406458 - Sequence 387482 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q96H86 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: A8MZF4, B3KSN2, ENST00000395091.1, ENST00000395091.2, H9KV99, NM_001172679, Q96H86, Q9BWS1, uc318xdn.1, uc318xdn.2, ZN764_HUMAN, ZNF764 UCSC ID: ENST00000395091.3_8 RefSeq Accession: NM_001172679.2 Protein: Q96H86 (aka ZN764_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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