Human Gene ZNF362 (ENST00000373428.5_1) from GENCODE V47lift37
  Description: zinc finger protein 362, transcript variant 2 (from RefSeq NM_001370212.1)
Gencode Transcript: ENST00000373428.5_1
Gencode Gene: ENSG00000160094.15_9
Transcript (Including UTRs)
   Position: hg19 chr1:33,736,176-33,766,320 Size: 30,145 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr1:33,736,176-33,764,647 Size: 28,472 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:33,736,176-33,766,320)mRNA (may differ from genome)Protein (420 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN362_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 362;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 6 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.43 RPKM in Artery - Aorta
Total median expression: 563.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -608.301673-0.364 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on Q5T0B9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF206631 - JP 2014500723-A/14134: Polycomb-Associated Non-Coding RNAs.
BC104779 - Homo sapiens zinc finger protein 362, mRNA (cDNA clone MGC:132439 IMAGE:8143782), complete cds.
BC112113 - Homo sapiens zinc finger protein 362, mRNA (cDNA clone MGC:138318 IMAGE:8327581), complete cds.
AF318356 - Homo sapiens pp6997 mRNA, complete cds.
EU446584 - Synthetic construct Homo sapiens clone IMAGE:100069999; IMAGE:100011793; FLH257185.01L FLJ25476 protein (FLJ25476) gene, encodes complete protein.
LF356734 - JP 2014500723-A/164237: Polycomb-Associated Non-Coding RNAs.
AK021842 - Homo sapiens cDNA FLJ11780 fis, clone HEMBA1005931, weakly similar to ZINC FINGER PROTEIN 83.
LF356728 - JP 2014500723-A/164231: Polycomb-Associated Non-Coding RNAs.
BC071632 - Homo sapiens FLJ25476 protein, mRNA (cDNA clone IMAGE:5582897).
JD478183 - Sequence 459207 from Patent EP1572962.
JD128717 - Sequence 109741 from Patent EP1572962.
JD055111 - Sequence 36135 from Patent EP1572962.
BC103704 - Homo sapiens cDNA clone IMAGE:6153184.
JD551334 - Sequence 532358 from Patent EP1572962.
LF356727 - JP 2014500723-A/164230: Polycomb-Associated Non-Coding RNAs.
AK098342 - Homo sapiens cDNA FLJ25476 fis, clone CBL03186.
BC065039 - Homo sapiens cDNA clone IMAGE:6147949, partial cds.
JD290906 - Sequence 271930 from Patent EP1572962.
JD045586 - Sequence 26610 from Patent EP1572962.
JD054619 - Sequence 35643 from Patent EP1572962.
JD123999 - Sequence 105023 from Patent EP1572962.
JD344110 - Sequence 325134 from Patent EP1572962.
JD186452 - Sequence 167476 from Patent EP1572962.
JD077666 - Sequence 58690 from Patent EP1572962.
JD307393 - Sequence 288417 from Patent EP1572962.
JD447786 - Sequence 428810 from Patent EP1572962.
JD372689 - Sequence 353713 from Patent EP1572962.
JD220610 - Sequence 201634 from Patent EP1572962.
JD200291 - Sequence 181315 from Patent EP1572962.
JD210737 - Sequence 191761 from Patent EP1572962.
LF356726 - JP 2014500723-A/164229: Polycomb-Associated Non-Coding RNAs.
JD156587 - Sequence 137611 from Patent EP1572962.
JD392250 - Sequence 373274 from Patent EP1572962.
MA442208 - JP 2018138019-A/14134: Polycomb-Associated Non-Coding RNAs.
MA592311 - JP 2018138019-A/164237: Polycomb-Associated Non-Coding RNAs.
MA592305 - JP 2018138019-A/164231: Polycomb-Associated Non-Coding RNAs.
MA592304 - JP 2018138019-A/164230: Polycomb-Associated Non-Coding RNAs.
MA592303 - JP 2018138019-A/164229: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000373428.1, ENST00000373428.2, ENST00000373428.3, ENST00000373428.4, NM_001370212, PP6997, Q5T0B9, Q8WYU4, uc318ktj.1, ZN362_HUMAN
UCSC ID: ENST00000373428.5_1
RefSeq Accession: NM_152493.3
Protein: Q5T0B9 (aka ZN362_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.