Human Gene ZNF264 (ENST00000263095.10_4) from GENCODE V47lift37

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Description: zinc finger protein 264 (from RefSeq NM_003417.5)
Gencode Transcript: ENST00000263095.10_4
Gencode Gene: ENSG00000083844.11_12
Transcript (Including UTRs)
Position: hg19 chr19:57,702,868-57,734,214 Size: 31,347 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chr19:57,703,282-57,724,349 Size: 21,068 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:57,702,868-57,734,214)			mRNA (may differ from genome)		Protein (627 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	Reactome	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZN264_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 264; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 13 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain. SEQUENCE CAUTION: Sequence=BAA24842.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003300 Copper D004397 Fonofos D005557 Formaldehyde D007854 Lead C558013 NSC 689534 D010278 Parathion D012643 Selenium D013749 Tetrachlorodibenzodioxin C447119 bazedoxifene C012568 terbufos more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 5.01 RPKM in Testis Total median expression: 74.47 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-204.00	414	-0.493	Picture	PostScript	Text
3' UTR	-3188.27	9865	-0.323	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
82657 - BolA-like
55550 - SH2 domain
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on O43296


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AK292504 - Homo sapiens cDNA FLJ76431 complete cds, highly similar to Homo sapiens zinc finger protein 264 (ZNF264), mRNA. AB007872 - Homo sapiens KIAA0412 mRNA. JD389856 - Sequence 370880 from Patent EP1572962. JD539198 - Sequence 520222 from Patent EP1572962. BC115411 - Homo sapiens zinc finger protein 264, mRNA (cDNA clone MGC:135042 IMAGE:40078437), complete cds. JD026943 - Sequence 7967 from Patent EP1572962. JD539196 - Sequence 520220 from Patent EP1572962. JD035830 - Sequence 16854 from Patent EP1572962. BC115410 - Homo sapiens zinc finger protein 264, mRNA (cDNA clone IMAGE:40078436), complete cds. JD336571 - Sequence 317595 from Patent EP1572962. JD191321 - Sequence 172345 from Patent EP1572962. JD464735 - Sequence 445759 from Patent EP1572962. JD355633 - Sequence 336657 from Patent EP1572962. AB385328 - Synthetic construct DNA, clone: pF1KA0412, Homo sapiens ZNF264 gene for zinc finger protein 264, complete cds, without stop codon, in Flexi system. KJ898020 - Synthetic construct Homo sapiens clone ccsbBroadEn_07414 ZNF264 gene, encodes complete protein. JD047389 - Sequence 28413 from Patent EP1572962. JD047389 - Sequence 28413 from Patent EP1572962. JD047389 - Sequence 28413 from Patent EP1572962. JD041514 - Sequence 22538 from Patent EP1572962. JD054293 - Sequence 35317 from Patent EP1572962. JD162834 - Sequence 143858 from Patent EP1572962. JD314796 - Sequence 295820 from Patent EP1572962. JD245328 - Sequence 226352 from Patent EP1572962. JD086924 - Sequence 67948 from Patent EP1572962. JD491335 - Sequence 472359 from Patent EP1572962. JD558166 - Sequence 539190 from Patent EP1572962. JD550598 - Sequence 531622 from Patent EP1572962. JD359350 - Sequence 340374 from Patent EP1572962. JD061565 - Sequence 42589 from Patent EP1572962. JD510717 - Sequence 491741 from Patent EP1572962. JD089501 - Sequence 70525 from Patent EP1572962. JD485695 - Sequence 466719 from Patent EP1572962. JD447227 - Sequence 428251 from Patent EP1572962. JD531575 - Sequence 512599 from Patent EP1572962. JD176004 - Sequence 157028 from Patent EP1572962. JD087668 - Sequence 68692 from Patent EP1572962. JD548236 - Sequence 529260 from Patent EP1572962. JD272231 - Sequence 253255 from Patent EP1572962. JD110413 - Sequence 91437 from Patent EP1572962. JD491707 - Sequence 472731 from Patent EP1572962. JD566845 - Sequence 547869 from Patent EP1572962. JD325842 - Sequence 306866 from Patent EP1572962. JD152940 - Sequence 133964 from Patent EP1572962. JD160729 - Sequence 141753 from Patent EP1572962. JD160730 - Sequence 141754 from Patent EP1572962. JD281383 - Sequence 262407 from Patent EP1572962. JD491962 - Sequence 472986 from Patent EP1572962. JD513439 - Sequence 494463 from Patent EP1572962. JD386488 - Sequence 367512 from Patent EP1572962. JD267940 - Sequence 248964 from Patent EP1572962. JD353170 - Sequence 334194 from Patent EP1572962. JD258877 - Sequence 239901 from Patent EP1572962. JD152388 - Sequence 133412 from Patent EP1572962. JD256886 - Sequence 237910 from Patent EP1572962. JD396152 - Sequence 377176 from Patent EP1572962. JD489030 - Sequence 470054 from Patent EP1572962. JD314594 - Sequence 295618 from Patent EP1572962. JD514680 - Sequence 495704 from Patent EP1572962. JD296869 - Sequence 277893 from Patent EP1572962. JD344816 - Sequence 325840 from Patent EP1572962. JD488497 - Sequence 469521 from Patent EP1572962. JD549037 - Sequence 530061 from Patent EP1572962. JD225405 - Sequence 206429 from Patent EP1572962. JD264907 - Sequence 245931 from Patent EP1572962. JD477572 - Sequence 458596 from Patent EP1572962. JD172989 - Sequence 154013 from Patent EP1572962. JD114036 - Sequence 95060 from Patent EP1572962. JD298799 - Sequence 279823 from Patent EP1572962. JD299055 - Sequence 280079 from Patent EP1572962. JD257967 - Sequence 238991 from Patent EP1572962. JD240585 - Sequence 221609 from Patent EP1572962. JD140453 - Sequence 121477 from Patent EP1572962. JD266884 - Sequence 247908 from Patent EP1572962. JD565951 - Sequence 546975 from Patent EP1572962. JD456597 - Sequence 437621 from Patent EP1572962. JD490605 - Sequence 471629 from Patent EP1572962. AK097167 - Homo sapiens cDNA FLJ39848 fis, clone SPLEN2014669. JD259524 - Sequence 240548 from Patent EP1572962. JD126142 - Sequence 107166 from Patent EP1572962. JD318847 - Sequence 299871 from Patent EP1572962. JD559535 - Sequence 540559 from Patent EP1572962. JD467188 - Sequence 448212 from Patent EP1572962. JD548575 - Sequence 529599 from Patent EP1572962. JD327033 - Sequence 308057 from Patent EP1572962. DQ579210 - Homo sapiens piRNA piR-47322, complete sequence. JD530906 - Sequence 511930 from Patent EP1572962. JD171812 - Sequence 152836 from Patent EP1572962. JD500439 - Sequence 481463 from Patent EP1572962. JD400116 - Sequence 381140 from Patent EP1572962. JD060673 - Sequence 41697 from Patent EP1572962. JD425559 - Sequence 406583 from Patent EP1572962. JD226286 - Sequence 207310 from Patent EP1572962. JD314546 - Sequence 295570 from Patent EP1572962. JD377905 - Sequence 358929 from Patent EP1572962. JD100981 - Sequence 82005 from Patent EP1572962. JD292134 - Sequence 273158 from Patent EP1572962. JD113530 - Sequence 94554 from Patent EP1572962. JD137602 - Sequence 118626 from Patent EP1572962. JD494145 - Sequence 475169 from Patent EP1572962. JD120931 - Sequence 101955 from Patent EP1572962. JD564270 - Sequence 545294 from Patent EP1572962. JD325714 - Sequence 306738 from Patent EP1572962. JD419292 - Sequence 400316 from Patent EP1572962. JD115711 - Sequence 96735 from Patent EP1572962. JD454174 - Sequence 435198 from Patent EP1572962. JD345630 - Sequence 326654 from Patent EP1572962. JD225343 - Sequence 206367 from Patent EP1572962. JD072288 - Sequence 53312 from Patent EP1572962. JD207602 - Sequence 188626 from Patent EP1572962. JD505485 - Sequence 486509 from Patent EP1572962. JD295402 - Sequence 276426 from Patent EP1572962. JD550523 - Sequence 531547 from Patent EP1572962. JD108110 - Sequence 89134 from Patent EP1572962. JD342189 - Sequence 323213 from Patent EP1572962. JD476931 - Sequence 457955 from Patent EP1572962. JD397715 - Sequence 378739 from Patent EP1572962. JD416191 - Sequence 397215 from Patent EP1572962. JD106819 - Sequence 87843 from Patent EP1572962. JD075159 - Sequence 56183 from Patent EP1572962. JD475688 - Sequence 456712 from Patent EP1572962. JD239645 - Sequence 220669 from Patent EP1572962. JD325895 - Sequence 306919 from Patent EP1572962. JD153094 - Sequence 134118 from Patent EP1572962. JD087014 - Sequence 68038 from Patent EP1572962. JD262019 - Sequence 243043 from Patent EP1572962. JD432394 - Sequence 413418 from Patent EP1572962. JD542611 - Sequence 523635 from Patent EP1572962. JD212505 - Sequence 193529 from Patent EP1572962. JD072055 - Sequence 53079 from Patent EP1572962. JD242995 - Sequence 224019 from Patent EP1572962. JD296883 - Sequence 277907 from Patent EP1572962. JD373535 - Sequence 354559 from Patent EP1572962. JD107540 - Sequence 88564 from Patent EP1572962. JD143793 - Sequence 124817 from Patent EP1572962. JD182942 - Sequence 163966 from Patent EP1572962. JD488038 - Sequence 469062 from Patent EP1572962. JD094289 - Sequence 75313 from Patent EP1572962. JD297168 - Sequence 278192 from Patent EP1572962. JD222896 - Sequence 203920 from Patent EP1572962. JD542803 - Sequence 523827 from Patent EP1572962. JD212777 - Sequence 193801 from Patent EP1572962. JD198173 - Sequence 179197 from Patent EP1572962. JD413479 - Sequence 394503 from Patent EP1572962. JD181948 - Sequence 162972 from Patent EP1572962. JD492641 - Sequence 473665 from Patent EP1572962. JD373423 - Sequence 354447 from Patent EP1572962. JD373424 - Sequence 354448 from Patent EP1572962. JD340985 - Sequence 322009 from Patent EP1572962. JD340986 - Sequence 322010 from Patent EP1572962. JD564305 - Sequence 545329 from Patent EP1572962. JD558246 - Sequence 539270 from Patent EP1572962. JD104979 - Sequence 86003 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O43296 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: A8K8Y9, ENST00000263095.1, ENST00000263095.2, ENST00000263095.3, ENST00000263095.4, ENST00000263095.5, ENST00000263095.6, ENST00000263095.7, ENST00000263095.8, ENST00000263095.9, KIAA0412, NM_003417, O43296, Q9P1V0, uc317hgp.1, uc317hgp.2, ZN264_HUMAN UCSC ID: ENST00000263095.10_4 RefSeq Accession: NM_003417.5 Protein: O43296 (aka ZN264_HUMAN or Z264_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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