Human Gene ZNF232 (ENST00000250076.8_11) from GENCODE V47lift37
  Description: zinc finger protein 232, transcript variant 1 (from RefSeq NM_014519.6)
Gencode Transcript: ENST00000250076.8_11
Gencode Gene: ENSG00000167840.14_15
Transcript (Including UTRs)
   Position: hg19 chr17:5,009,031-5,015,173 Size: 6,143 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr17:5,009,119-5,015,117 Size: 5,999 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:5,009,031-5,015,173)mRNA (may differ from genome)Protein (444 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN232_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 232; AltName: Full=Zinc finger and SCAN domain-containing protein 11;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous. Higher expression seen in the liver, testis and ovary.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SIMILARITY: Contains 1 SCAN box domain.
SEQUENCE CAUTION: Sequence=AAH16039.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.23 RPKM in Testis
Total median expression: 153.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.1056-0.359 Picture PostScript Text
3' UTR -15.2088-0.173 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF02023 - SCAN domain
PF13912 - C2H2-type zinc finger

SCOP Domains:
47353 - Retrovirus capsid dimerization domain-like
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on Q9UNY5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC002852 - Homo sapiens mRNA similar to zinc finger protein 232 (cDNA clone IMAGE:3634328).
AK057506 - Homo sapiens cDNA FLJ32944 fis, clone TESTI2007864, highly similar to Zinc finger protein 232.
AK225622 - Homo sapiens mRNA for zinc finger protein 232 variant, clone: SPL00634.
BC016039 - Homo sapiens zinc finger protein 232, mRNA (cDNA clone MGC:19949 IMAGE:4635999), complete cds.
Y15067 - Homo sapiens mRNA for Zn-finger protein ZNF232.
JD045592 - Sequence 26616 from Patent EP1572962.
JD483918 - Sequence 464942 from Patent EP1572962.
KJ901847 - Synthetic construct Homo sapiens clone ccsbBroadEn_11241 ZNF232 gene, encodes complete protein.
EU446923 - Synthetic construct Homo sapiens clone IMAGE:100070097; IMAGE:100012132; FLH257472.01L zinc finger protein 232 (ZNF232) gene, encodes complete protein.
AB527762 - Synthetic construct DNA, clone: pF1KB7992, Homo sapiens ZNF232 gene for zinc finger protein 232, without stop codon, in Flexi system.
AK298190 - Homo sapiens cDNA FLJ60752 complete cds, highly similar to Zinc finger protein 232.
JD314870 - Sequence 295894 from Patent EP1572962.
CU677555 - Synthetic construct Homo sapiens gateway clone IMAGE:100019303 5' read ZNF232 mRNA.
AK297835 - Homo sapiens cDNA FLJ55150 complete cds, highly similar to Homo sapiens zinc finger protein 232 (ZNF232), mRNA.
AK316369 - Homo sapiens cDNA, FLJ79268 complete cds, highly similar to Zinc finger protein 232.
JD156081 - Sequence 137105 from Patent EP1572962.
JD402757 - Sequence 383781 from Patent EP1572962.
JD486753 - Sequence 467777 from Patent EP1572962.
JD333632 - Sequence 314656 from Patent EP1572962.
JD221615 - Sequence 202639 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000250076.1, ENST00000250076.2, ENST00000250076.3, ENST00000250076.4, ENST00000250076.5, ENST00000250076.6, ENST00000250076.7, I3L4J6, NM_014519, Q9UNY5, uc317fat.1, uc317fat.2, ZN232_HUMAN, ZSCAN11
UCSC ID: ENST00000250076.8_11
RefSeq Accession: NM_014519.6
Protein: Q9UNY5 (aka ZN232_HUMAN or Z232_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.