Human Gene ZNF10 (ENST00000248211.11_4) from GENCODE V47lift37
  Description: zinc finger protein 10 (from RefSeq NM_015394.5)
Gencode Transcript: ENST00000248211.11_4
Gencode Gene: ENSG00000256223.6_14
Transcript (Including UTRs)
   Position: hg19 chr12:133,707,213-133,736,051 Size: 28,839 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr12:133,721,079-133,733,554 Size: 12,476 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:133,707,213-133,736,051)mRNA (may differ from genome)Protein (573 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNF10_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 10; AltName: Full=Zinc finger protein KOX1;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.59 RPKM in Pituitary
Total median expression: 23.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.20187-0.290 Picture PostScript Text
3' UTR -582.202497-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on P21506
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK314784 - Homo sapiens cDNA, FLJ95654, Homo sapiens zinc finger protein 10 (KOX 1) (ZNF10), mRNA.
BC024182 - Homo sapiens zinc finger protein 10, mRNA (cDNA clone MGC:26561 IMAGE:4823159), complete cds.
AK302159 - Homo sapiens cDNA FLJ51381 complete cds, highly similar to Zinc finger protein 268.
JD292727 - Sequence 273751 from Patent EP1572962.
X52332 - Homo sapiens mRNA for zinc finger protein 10.
JD110863 - Sequence 91887 from Patent EP1572962.
CU692866 - Synthetic construct Homo sapiens gateway clone IMAGE:100020401 5' read ZNF10 mRNA.
KJ897755 - Synthetic construct Homo sapiens clone ccsbBroadEn_07149 ZNF10 gene, encodes complete protein.
AB384891 - Synthetic construct DNA, clone: pF1KB4076, Homo sapiens ZNF10 gene for zinc finger protein 10, complete cds, without stop codon, in Flexi system.
EU446718 - Synthetic construct Homo sapiens clone IMAGE:100070236; IMAGE:100011927; FLH258181.01L zinc finger protein 10 (ZNF10) gene, encodes complete protein.
AL110188 - Homo sapiens mRNA; cDNA DKFZp434G1621 (from clone DKFZp434G1621).
JD032199 - Sequence 13223 from Patent EP1572962.
JD314875 - Sequence 295899 from Patent EP1572962.
JD331477 - Sequence 312501 from Patent EP1572962.
JD375525 - Sequence 356549 from Patent EP1572962.
JD053099 - Sequence 34123 from Patent EP1572962.
JD315347 - Sequence 296371 from Patent EP1572962.
JD301993 - Sequence 283017 from Patent EP1572962.
JD494146 - Sequence 475170 from Patent EP1572962.
JD359608 - Sequence 340632 from Patent EP1572962.
JD091106 - Sequence 72130 from Patent EP1572962.
JD110832 - Sequence 91856 from Patent EP1572962.
JD491826 - Sequence 472850 from Patent EP1572962.
JD429791 - Sequence 410815 from Patent EP1572962.
JD232545 - Sequence 213569 from Patent EP1572962.
JD235207 - Sequence 216231 from Patent EP1572962.
JD196207 - Sequence 177231 from Patent EP1572962.
JD448848 - Sequence 429872 from Patent EP1572962.
JD040526 - Sequence 21550 from Patent EP1572962.
JD052937 - Sequence 33961 from Patent EP1572962.
JD501376 - Sequence 482400 from Patent EP1572962.
JD295559 - Sequence 276583 from Patent EP1572962.
JD292186 - Sequence 273210 from Patent EP1572962.
JD182075 - Sequence 163099 from Patent EP1572962.
JD350832 - Sequence 331856 from Patent EP1572962.
JD224142 - Sequence 205166 from Patent EP1572962.
JD504316 - Sequence 485340 from Patent EP1572962.
JD088442 - Sequence 69466 from Patent EP1572962.
JD409903 - Sequence 390927 from Patent EP1572962.
JD530777 - Sequence 511801 from Patent EP1572962.
JD502072 - Sequence 483096 from Patent EP1572962.
JD236628 - Sequence 217652 from Patent EP1572962.
JD084282 - Sequence 65306 from Patent EP1572962.
JD101266 - Sequence 82290 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P21506 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B2RBS1, ENST00000248211.1, ENST00000248211.10, ENST00000248211.2, ENST00000248211.3, ENST00000248211.4, ENST00000248211.5, ENST00000248211.6, ENST00000248211.7, ENST00000248211.8, ENST00000248211.9, KOX1, NM_015394, P21506, Q8TC91, uc317exc.1, uc317exc.2, ZNF10_HUMAN
UCSC ID: ENST00000248211.11_4
RefSeq Accession: NM_015394.5
Protein: P21506 (aka ZNF10_HUMAN or ZN10_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.