ID:TUT4_HUMAN DESCRIPTION: RecName: Full=Terminal uridylyltransferase 4; Short=TUTase 4; EC=2.7.7.52; AltName: Full=Zinc finger CCHC domain-containing protein 11; FUNCTION: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. CATALYTIC ACTIVITY: UTP + RNA(n) = diphosphate + RNA(n+1). COFACTOR: Magnesium or manganese (By similarity). SUBUNIT: Interacts with LIN28A, LIN28B and T2BP. INTERACTION: Q96CG3:TIFA; NbExp=2; IntAct=EBI-1606425, EBI-740711; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the DNA polymerase type-B-like family. SIMILARITY: Contains 3 CCHC-type zinc fingers. SIMILARITY: Contains 2 PAP-associated domains. SEQUENCE CAUTION: Sequence=CAI23477.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5TAX3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
