Human Gene ZC3H12C (ENST00000278590.8_4) from GENCODE V47lift37
  Description: zinc finger CCCH-type containing 12C (from RefSeq NM_033390.2)
Gencode Transcript: ENST00000278590.8_4
Gencode Gene: ENSG00000149289.11_14
Transcript (Including UTRs)
   Position: hg19 chr11:109,964,118-110,042,566 Size: 78,449 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr11:109,964,138-110,036,462 Size: 72,325 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:109,964,118-110,042,566)mRNA (may differ from genome)Protein (883 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZC12C_HUMAN
DESCRIPTION: RecName: Full=Probable ribonuclease ZC3H12C; EC=3.1.-.-; AltName: Full=MCP-induced protein 3; AltName: Full=Zinc finger CCCH domain-containing protein 12C;
FUNCTION: May function as RNase and regulate the levels of target RNA species (Potential).
COFACTOR: Magnesium (Potential).
INDUCTION: By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.
SIMILARITY: Belongs to the ZC3H12 family.
SIMILARITY: Contains 1 C3H1-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.52 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 120.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.0020-0.150 Picture PostScript Text
3' UTR -1500.806104-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021869 - RNase_Zc3h12
IPR000571 - Znf_CCCH

Pfam Domains:
PF11977 - Zc3h12a-like Ribonuclease NYN domain
PF14608 - RNA-binding, Nab2-type zinc finger
PF18039 - UBA-like domain
PF18561 - Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain

SCOP Domains:
57059 - omega toxin-like
90229 - CCCH zinc finger

ModBase Predicted Comparative 3D Structure on Q9C0D7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0008150 biological_process
GO:0090305 nucleic acid phosphodiester bond hydrolysis

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  AK095101 - Homo sapiens cDNA FLJ37782 fis, clone BRHIP2027762.
AB384628 - Synthetic construct DNA, clone: pF1KA1726, Homo sapiens ZC3H12C gene for zinc finger CCCH-type containing protein 12C, complete cds, without stop codon, in Flexi system.
AK295437 - Homo sapiens cDNA FLJ55974 complete cds, moderately similar to Homo sapiens zinc finger CCCH-type containing 12A (ZC3H12A), mRNA.
AK299100 - Homo sapiens cDNA FLJ55575 complete cds, moderately similar to Homo sapiens zinc finger CCCH-type containing 12A (ZC3H12A), mRNA.
AB096241 - Homo sapiens LOH11CR1B gene, loss of heterozygosity, 11, chromosomal region 1 gene B product.
AB051513 - Homo sapiens mRNA for KIAA1726 protein, partial cds.
JD065770 - Sequence 46794 from Patent EP1572962.
JD287421 - Sequence 268445 from Patent EP1572962.
AL832893 - Homo sapiens mRNA; cDNA DKFZp667A024 (from clone DKFZp667A024).
JD085902 - Sequence 66926 from Patent EP1572962.
JD280932 - Sequence 261956 from Patent EP1572962.
JD510109 - Sequence 491133 from Patent EP1572962.
JD114605 - Sequence 95629 from Patent EP1572962.
JD237366 - Sequence 218390 from Patent EP1572962.
JD515909 - Sequence 496933 from Patent EP1572962.
JD392372 - Sequence 373396 from Patent EP1572962.
JD303788 - Sequence 284812 from Patent EP1572962.
JD502159 - Sequence 483183 from Patent EP1572962.
JD168303 - Sequence 149327 from Patent EP1572962.
JD324622 - Sequence 305646 from Patent EP1572962.
JD040238 - Sequence 21262 from Patent EP1572962.
JD314769 - Sequence 295793 from Patent EP1572962.
JD357305 - Sequence 338329 from Patent EP1572962.
JD319022 - Sequence 300046 from Patent EP1572962.
JD313194 - Sequence 294218 from Patent EP1572962.
JD159350 - Sequence 140374 from Patent EP1572962.
JD495326 - Sequence 476350 from Patent EP1572962.
JD263280 - Sequence 244304 from Patent EP1572962.
JD418121 - Sequence 399145 from Patent EP1572962.
JD042010 - Sequence 23034 from Patent EP1572962.
JD502161 - Sequence 483185 from Patent EP1572962.
JD502133 - Sequence 483157 from Patent EP1572962.
JD432843 - Sequence 413867 from Patent EP1572962.
JD263032 - Sequence 244056 from Patent EP1572962.
JD116432 - Sequence 97456 from Patent EP1572962.
JD304686 - Sequence 285710 from Patent EP1572962.
JD316398 - Sequence 297422 from Patent EP1572962.
JD244881 - Sequence 225905 from Patent EP1572962.
JD359301 - Sequence 340325 from Patent EP1572962.
JD288111 - Sequence 269135 from Patent EP1572962.
JD414677 - Sequence 395701 from Patent EP1572962.
JD040879 - Sequence 21903 from Patent EP1572962.
JD283584 - Sequence 264608 from Patent EP1572962.
JD225815 - Sequence 206839 from Patent EP1572962.
JD454567 - Sequence 435591 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DI65, B4DR47, ENST00000278590.1, ENST00000278590.2, ENST00000278590.3, ENST00000278590.4, ENST00000278590.5, ENST00000278590.6, ENST00000278590.7, KIAA1726, MCPIP3, NM_033390, Q9C0D7, uc317jpe.1, uc317jpe.2, ZC12C_HUMAN
UCSC ID: ENST00000278590.8_4
RefSeq Accession: NM_033390.2
Protein: Q9C0D7 (aka ZC12C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.