Human Gene ZBTB8A (ENST00000373510.9_4) from GENCODE V47lift37

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Description: zinc finger and BTB domain containing 8A, transcript variant 3 (from RefSeq NR_111980.2)
Gencode Transcript: ENST00000373510.9_4
Gencode Gene: ENSG00000160062.15_8
Transcript (Including UTRs)
Position: hg19 chr1:33,005,028-33,071,542 Size: 66,515 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr1:33,058,533-33,066,020 Size: 7,488 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:33,005,028-33,071,542)			mRNA (may differ from genome)		Protein (441 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZBT8A_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 8A; AltName: Full=BTB/POZ and zinc-finger domain-containing factor; AltName: Full=BTB/POZ and zinc-finger domains factor on chromosome 1; Short=BOZ-F1; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 2 C2H2-type zinc fingers.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001151 Arsenic D016572 Cyclosporine D003993 Dibutyl Phthalate D015125 Oxyquinoline

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 1.57 RPKM in Cervix - Endocervix Total median expression: 21.67 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-69.70	229	-0.304	Picture	PostScript	Text
3' UTR	-2005.50	5522	-0.363	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF11822 - Domain of unknown function (DUF3342)
PF13912 - C2H2-type zinc finger

SCOP Domains:
54695 - POZ domain
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon

ModBase Predicted Comparative 3D Structure on Q96BR9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0008150 biological_process Cellular Component: GO:0005575 cellular_component GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AK092326 - Homo sapiens cDNA FLJ35007 fis, clone OCBBF2012095, weakly similar to ZINC FINGER PROTEIN 151. AX747483 - Sequence 1008 from Patent EP1308459. AK074546 - Homo sapiens cDNA FLJ90065 fis, clone HEMBA1003497, weakly similar to ZINC FINGER PROTEIN 151. AY157873 - Homo sapiens BTB/POZ and zinc-finger domain containing factor variant L (BOZF1) mRNA, complete cds; alternatively spliced. BC015239 - Homo sapiens zinc finger and BTB domain containing 8, mRNA (cDNA clone MGC:17919 IMAGE:3914043), complete cds. AF548353 - Homo sapiens BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZF1) mRNA, complete cds. DQ500954 - Homo sapiens B-twin factor (ZBTB8) mRNA, partial cds. JD382127 - Sequence 363151 from Patent EP1572962. CU677249 - Synthetic construct Homo sapiens gateway clone IMAGE:100017275 5' read ZBTB8 mRNA. HQ448223 - Synthetic construct Homo sapiens clone IMAGE:100071624; CCSB000784_01 zinc finger and BTB domain containing 8 (ZBTB8) gene, encodes complete protein. KJ901092 - Synthetic construct Homo sapiens clone ccsbBroadEn_10486 ZBTB8A gene, encodes complete protein. JD553524 - Sequence 534548 from Patent EP1572962. JD462712 - Sequence 443736 from Patent EP1572962. JD346346 - Sequence 327370 from Patent EP1572962. JD268142 - Sequence 249166 from Patent EP1572962. JD429380 - Sequence 410404 from Patent EP1572962. JD500709 - Sequence 481733 from Patent EP1572962. JD249067 - Sequence 230091 from Patent EP1572962. BC029654 - Homo sapiens zinc finger and BTB domain containing 8, mRNA (cDNA clone IMAGE:4751583), partial cds. JD454873 - Sequence 435897 from Patent EP1572962. BC015067 - Homo sapiens zinc finger and BTB domain containing 8, mRNA (cDNA clone IMAGE:3930972), partial cds. JD098151 - Sequence 79175 from Patent EP1572962. JD379189 - Sequence 360213 from Patent EP1572962. JD516173 - Sequence 497197 from Patent EP1572962. JD307589 - Sequence 288613 from Patent EP1572962. JD181820 - Sequence 162844 from Patent EP1572962. JD326978 - Sequence 308002 from Patent EP1572962. JD062357 - Sequence 43381 from Patent EP1572962. JD446406 - Sequence 427430 from Patent EP1572962. JD291772 - Sequence 272796 from Patent EP1572962. JD446407 - Sequence 427431 from Patent EP1572962. JD175689 - Sequence 156713 from Patent EP1572962. JD340974 - Sequence 321998 from Patent EP1572962. JD340975 - Sequence 321999 from Patent EP1572962. JD529617 - Sequence 510641 from Patent EP1572962. JD170095 - Sequence 151119 from Patent EP1572962. JD170096 - Sequence 151120 from Patent EP1572962. JD400376 - Sequence 381400 from Patent EP1572962. JD424825 - Sequence 405849 from Patent EP1572962. JD080260 - Sequence 61284 from Patent EP1572962. JD150765 - Sequence 131789 from Patent EP1572962. JD525895 - Sequence 506919 from Patent EP1572962. JD422114 - Sequence 403138 from Patent EP1572962. JD294865 - Sequence 275889 from Patent EP1572962. JD507297 - Sequence 488321 from Patent EP1572962. JD238485 - Sequence 219509 from Patent EP1572962. JD047780 - Sequence 28804 from Patent EP1572962. JD425466 - Sequence 406490 from Patent EP1572962. JD110529 - Sequence 91553 from Patent EP1572962. JD050593 - Sequence 31617 from Patent EP1572962. JD269649 - Sequence 250673 from Patent EP1572962. JD364610 - Sequence 345634 from Patent EP1572962. JD189792 - Sequence 170816 from Patent EP1572962. JD318885 - Sequence 299909 from Patent EP1572962. JD367564 - Sequence 348588 from Patent EP1572962. JD366817 - Sequence 347841 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: BOZF1, ENST00000373510.1, ENST00000373510.2, ENST00000373510.3, ENST00000373510.4, ENST00000373510.5, ENST00000373510.6, ENST00000373510.7, ENST00000373510.8, NR_111980, Q8IUL5, Q8IWR9, Q8N2Y5, Q96BR9, Q96BX0, uc318kvf.1, uc318kvf.2, ZBT8A_HUMAN UCSC ID: ENST00000373510.9_4 RefSeq Accession: NM_001040441.3 Protein: Q96BR9 (aka ZBT8A_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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