Human Gene ZBTB43 (ENST00000373464.5_4) from GENCODE V47lift37

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Description: zinc finger and BTB domain containing 43, transcript variant 1 (from RefSeq NM_014007.4)
Gencode Transcript: ENST00000373464.5_4
Gencode Gene: ENSG00000169155.10_11
Transcript (Including UTRs)
Position: hg19 chr9:129,567,319-129,600,489 Size: 33,171 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr9:129,594,789-129,596,192 Size: 1,404 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:129,567,319-129,600,489)			mRNA (may differ from genome)		Protein (467 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZBT43_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 43; AltName: Full=Zinc finger and BTB domain-containing protein 22B; AltName: Full=Zinc finger protein 297B; AltName: Full=ZnF-x; FUNCTION: May be involved in transcriptional regulation. SUBUNIT: Interacts with BDP1. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 3 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAA24844.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C035207 4-amino-2,6-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D003300 Copper D019327 Copper Sulfate D016572 Cyclosporine D004958 Estradiol D006861 Hydrogen Peroxide more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 11.08 RPKM in Muscle - Skeletal Total median expression: 187.81 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-75.40	239	-0.315	Picture	PostScript	Text
3' UTR	-1269.30	4297	-0.295	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain
57667 - beta-beta-alpha zinc fingers

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2CSH - NMR MuPIT

ModBase Predicted Comparative 3D Structure on O43298


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AF049907 - Homo sapiens zinc finger transcription factor (ZNF-X) mRNA, complete cds. AK026123 - Homo sapiens cDNA: FLJ22470 fis, clone HRC10506, highly similar to AF049907 Homo sapiens zinc finger transcription factor (ZNF-X) mRNA. BC008828 - Homo sapiens zinc finger and BTB domain containing 43, mRNA (cDNA clone MGC:12781 IMAGE:4123095), complete cds. AB007874 - Homo sapiens KIAA0414 mRNA. CU679133 - Synthetic construct Homo sapiens gateway clone IMAGE:100017331 5' read ZBTB43 mRNA. AB383876 - Synthetic construct DNA, clone: pF1KSDA0414, Homo sapiens ZBTB43 gene for zinc finger and BTB domain-containing protein 43, complete cds, without stop codon, in Flexi system. BT007194 - Homo sapiens zinc finger protein 297B mRNA, complete cds. KJ898444 - Synthetic construct Homo sapiens clone ccsbBroadEn_07838 ZBTB43 gene, encodes complete protein. JD450657 - Sequence 431681 from Patent EP1572962. JD539664 - Sequence 520688 from Patent EP1572962. JD184507 - Sequence 165531 from Patent EP1572962. JD341737 - Sequence 322761 from Patent EP1572962. JD267059 - Sequence 248083 from Patent EP1572962. JD092915 - Sequence 73939 from Patent EP1572962. JD527963 - Sequence 508987 from Patent EP1572962. JD426883 - Sequence 407907 from Patent EP1572962. JD097922 - Sequence 78946 from Patent EP1572962. JD045939 - Sequence 26963 from Patent EP1572962. JD380137 - Sequence 361161 from Patent EP1572962. JD040880 - Sequence 21904 from Patent EP1572962. JD083903 - Sequence 64927 from Patent EP1572962. JD166561 - Sequence 147585 from Patent EP1572962. JD052817 - Sequence 33841 from Patent EP1572962. JD319986 - Sequence 301010 from Patent EP1572962. JD313301 - Sequence 294325 from Patent EP1572962. JD412056 - Sequence 393080 from Patent EP1572962. JD315544 - Sequence 296568 from Patent EP1572962. JD410789 - Sequence 391813 from Patent EP1572962. JD365967 - Sequence 346991 from Patent EP1572962. JD103911 - Sequence 84935 from Patent EP1572962. JD539412 - Sequence 520436 from Patent EP1572962. JD175333 - Sequence 156357 from Patent EP1572962. JD428040 - Sequence 409064 from Patent EP1572962. JD299617 - Sequence 280641 from Patent EP1572962. JD563818 - Sequence 544842 from Patent EP1572962. JD443769 - Sequence 424793 from Patent EP1572962. JD559763 - Sequence 540787 from Patent EP1572962. JD540744 - Sequence 521768 from Patent EP1572962. JD048379 - Sequence 29403 from Patent EP1572962. JD076994 - Sequence 58018 from Patent EP1572962. JD185864 - Sequence 166888 from Patent EP1572962. JD185863 - Sequence 166887 from Patent EP1572962. JD101923 - Sequence 82947 from Patent EP1572962. JD101924 - Sequence 82948 from Patent EP1572962. JD101922 - Sequence 82946 from Patent EP1572962. JD561346 - Sequence 542370 from Patent EP1572962. JD561347 - Sequence 542371 from Patent EP1572962. JD481354 - Sequence 462378 from Patent EP1572962. JD481355 - Sequence 462379 from Patent EP1572962. JD179696 - Sequence 160720 from Patent EP1572962. JD421962 - Sequence 402986 from Patent EP1572962. JD341081 - Sequence 322105 from Patent EP1572962. JD069286 - Sequence 50310 from Patent EP1572962. JD406615 - Sequence 387639 from Patent EP1572962. JD461011 - Sequence 442035 from Patent EP1572962. JD139587 - Sequence 120611 from Patent EP1572962. JD183810 - Sequence 164834 from Patent EP1572962. JD292358 - Sequence 273382 from Patent EP1572962. JD534379 - Sequence 515403 from Patent EP1572962. JD364212 - Sequence 345236 from Patent EP1572962. JD517282 - Sequence 498306 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000373464.1, ENST00000373464.2, ENST00000373464.3, ENST00000373464.4, KIAA0414, NM_014007, O43298, Q5JU96, uc318kub.1, uc318kub.2, ZBT43_HUMAN, ZBTB22B, ZNF297B UCSC ID: ENST00000373464.5_4 RefSeq Accession: NM_014007.4 Protein: O43298 (aka ZBT43_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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