Human Gene WNT9B (ENST00000290015.7_4) from GENCODE V47lift37
  Description: Wnt family member 9B, transcript variant 1 (from RefSeq NM_003396.3)
Gencode Transcript: ENST00000290015.7_4
Gencode Gene: ENSG00000158955.11_10
Transcript (Including UTRs)
   Position: hg19 chr17:44,928,949-44,957,926 Size: 28,978 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr17:44,929,005-44,954,084 Size: 25,080 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:44,928,949-44,957,926)mRNA (may differ from genome)Protein (357 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: WNT9B_HUMAN
DESCRIPTION: RecName: Full=Protein Wnt-9b; AltName: Full=Protein Wnt-14b; AltName: Full=Protein Wnt-15; Flags: Precursor;
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
SUBUNIT: Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Moderately expressed in fetal kidney and adult kidney. Also found in brain.
PTM: Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-89. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).
SIMILARITY: Belongs to the Wnt family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: WNT9B
Diseases sorted by gene-association score: mayer-rokitansky-kuster-hauser syndrome (11), exstrophy of bladder (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.34 RPKM in Kidney - Cortex
Total median expression: 4.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.9056-0.355 Picture PostScript Text
3' UTR -1455.103842-0.379 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005817 - Wnt
IPR026535 - Wnt9
IPR018161 - Wnt_CS

Pfam Domains:
PF00110 - wnt family

ModBase Predicted Comparative 3D Structure on O14905
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0039706 co-receptor binding
GO:0048018 receptor agonist activity

Biological Process:
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001932 regulation of protein phosphorylation
GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0009267 cellular response to starvation
GO:0009786 regulation of asymmetric cell division
GO:0010469 regulation of receptor activity
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030539 male genitalia development
GO:0032526 response to retinoic acid
GO:0035150 regulation of tube size
GO:0043085 positive regulation of catalytic activity
GO:0045165 cell fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060993 kidney morphogenesis
GO:0061038 uterus morphogenesis
GO:0061303 cornea development in camera-type eye
GO:0071300 cellular response to retinoic acid
GO:0072003 kidney rudiment formation
GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis
GO:0072044 collecting duct development
GO:0072046 establishment of planar polarity involved in nephron morphogenesis
GO:0072078 nephron tubule morphogenesis
GO:0072164 mesonephric tubule development
GO:0072170 metanephric tubule development
GO:0072174 metanephric tubule formation
GO:0072181 mesonephric duct formation
GO:1902455 negative regulation of stem cell population maintenance
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1905438 non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC064534 - Homo sapiens wingless-type MMTV integration site family, member 9B, mRNA (cDNA clone MGC:70631 IMAGE:5588904), complete cds.
KJ901827 - Synthetic construct Homo sapiens clone ccsbBroadEn_11221 WNT9B gene, encodes complete protein.
AK127268 - Homo sapiens cDNA FLJ45335 fis, clone BRHIP3007424, moderately similar to WNT-14 protein precursor.
AK127615 - Homo sapiens cDNA FLJ45713 fis, clone FEKID2002493, moderately similar to WNT-14 protein precursor.
AY358217 - Homo sapiens clone DNA178511 WNT9B (UNQ6973) mRNA, complete cds.
AB063483 - Homo sapiens mRNA for WNT14B, complete cds.
AB590853 - Synthetic construct DNA, clone: pFN21AE1840, Homo sapiens WNT9B gene for wingless-type MMTV integration site family, member 9B, without stop codon, in Flexi system.
JD158546 - Sequence 139570 from Patent EP1572962.
JD546793 - Sequence 527817 from Patent EP1572962.
JD521752 - Sequence 502776 from Patent EP1572962.
JD180864 - Sequence 161888 from Patent EP1572962.
JD306146 - Sequence 287170 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O14905 (Reactome details) participates in the following event(s):

R-HSA-201708 Frizzled receptors bind Wnts
R-HSA-3238694 PORCN palmitoleoylates N-glycosyl WNTs
R-HSA-3247843 secretion of WNT ligands
R-HSA-3247840 WLS binds WNT ligands in the Golgi
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-500792 GPCR ligand binding
R-HSA-195721 Signaling by WNT
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000290015.1, ENST00000290015.2, ENST00000290015.3, ENST00000290015.4, ENST00000290015.5, ENST00000290015.6, NM_003396, O14905, Q6UXT4, Q96Q09, uc317ktn.1, uc317ktn.2, UNQ6973/PRO21956, WNT14B , WNT15, WNT9B_HUMAN
UCSC ID: ENST00000290015.7_4
RefSeq Accession: NM_003396.3
Protein: O14905 (aka WNT9B_HUMAN or WN9B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.