Human Gene WNT8A (ENST00000506684.6_4) from GENCODE V47lift37
  Description: Wnt family member 8A, transcript variant 2 (from RefSeq NM_001300939.2)
Gencode Transcript: ENST00000506684.6_4
Gencode Gene: ENSG00000061492.12_9
Transcript (Including UTRs)
   Position: hg19 chr5:137,419,722-137,427,230 Size: 7,509 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr5:137,419,817-137,426,762 Size: 6,946 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:137,419,722-137,427,230)mRNA (may differ from genome)Protein (369 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: D6RF47_HUMAN
DESCRIPTION: RecName: Full=Protein Wnt;
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
SIMILARITY: Belongs to the Wnt family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.80 RPKM in Testis
Total median expression: 2.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.8095-0.387 Picture PostScript Text
3' UTR -144.90468-0.310 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005817 - Wnt
IPR013301 - Wnt8
IPR018161 - Wnt_CS

Pfam Domains:
PF00110 - wnt family

ModBase Predicted Comparative 3D Structure on D6RF47
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding

Biological Process:
GO:0000902 cell morphogenesis
GO:0003002 regionalization
GO:0007275 multicellular organism development
GO:0007492 endoderm development
GO:0009949 polarity specification of anterior/posterior axis
GO:0010085 polarity specification of proximal/distal axis
GO:0016055 Wnt signaling pathway
GO:0032880 regulation of protein localization
GO:0048561 establishment of animal organ orientation

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  BC144497 - Homo sapiens cDNA clone IMAGE:9053024, containing frame-shift errors.
AY009402 - Homo sapiens WNT8d precursor (WNT8d) mRNA, complete cds.
BC144001 - Homo sapiens cDNA clone IMAGE:9052519, with apparent retained intron.
JD157487 - Sequence 138511 from Patent EP1572962.
JD271049 - Sequence 252073 from Patent EP1572962.
JD418534 - Sequence 399558 from Patent EP1572962.
AB057725 - Homo sapiens mRNA for WNT8A, complete cds.
AB590697 - Synthetic construct DNA, clone: pFN21AE1833, Homo sapiens WNT8A gene for wingless-type MMTV integration site family, member 8A, without stop codon, in Flexi system.
BC156844 - Synthetic construct Homo sapiens clone IMAGE:100062529, MGC:190545 wingless-type MMTV integration site family, member 8A (WNT8A) mRNA, encodes complete protein.
DQ570282 - Homo sapiens piRNA piR-30394, complete sequence.
JD227012 - Sequence 208036 from Patent EP1572962.
JD423444 - Sequence 404468 from Patent EP1572962.
JD179599 - Sequence 160623 from Patent EP1572962.
JD401231 - Sequence 382255 from Patent EP1572962.
JD528889 - Sequence 509913 from Patent EP1572962.
JD168515 - Sequence 149539 from Patent EP1572962.
JD265619 - Sequence 246643 from Patent EP1572962.
JD377223 - Sequence 358247 from Patent EP1572962.
JD263006 - Sequence 244030 from Patent EP1572962.
JD359164 - Sequence 340188 from Patent EP1572962.
JD297024 - Sequence 278048 from Patent EP1572962.
JD231233 - Sequence 212257 from Patent EP1572962.
JD323752 - Sequence 304776 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_wnt-lrp6Pathway - Wnt/LRP6 Signalling

-  Other Names for This Gene
  Alternate Gene Symbols: D6RF47, D6RF47_HUMAN, ENST00000506684.1, ENST00000506684.2, ENST00000506684.3, ENST00000506684.4, ENST00000506684.5, NM_001300939, uc323bkt.1, uc323bkt.2, WNT8A
UCSC ID: ENST00000506684.6_4
RefSeq Accession: NM_001300939.2
Protein: D6RF47

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.