ID:UB2L6_HUMAN DESCRIPTION: RecName: Full=Ubiquitin/ISG15-conjugating enzyme E2 L6; EC=6.3.2.19; AltName: Full=Retinoic acid-induced gene B protein; Short=RIG-B; AltName: Full=UbcH8; AltName: Full=Ubiquitin carrier protein L6; AltName: Full=Ubiquitin-protein ligase L6; FUNCTION: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated). INTERACTION: Q6ZMZ0:RNF19B; NbExp=3; IntAct=EBI-2129974, EBI-2466594; Q8CJB9:Rnf40 (xeno); NbExp=2; IntAct=EBI-2129974, EBI-6110162; TISSUE SPECIFICITY: Present in natural killer cells (at protein level). INDUCTION: By IFNB1/IFN-beta. PTM: ISGylated. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SEQUENCE CAUTION: Sequence=CAB64566.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14933
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006464 cellular protein modification process GO:0016567 protein ubiquitination GO:0019941 modification-dependent protein catabolic process GO:0019985 translesion synthesis GO:0032020 ISG15-protein conjugation GO:0032480 negative regulation of type I interferon production GO:0044267 cellular protein metabolic process
AK093462 - Homo sapiens cDNA FLJ36143 fis, clone TESTI2025013, highly similar to UBIQUITIN-CONJUGATING ENZYME E2-18 KDA UBCH8 (EC 6.3.2.19). AK129621 - Homo sapiens cDNA FLJ26110 fis, clone SPL05701, highly similar to Ubiquitin-conjugating enzyme E2-18 kDa UBCH8 (EC 6.3.2.19). AF061736 - Homo sapiens ubiquitin-conjugating enzyme RIG-B mRNA, complete cds. BC032491 - Homo sapiens ubiquitin-conjugating enzyme E2L 6, mRNA (cDNA clone MGC:40331 IMAGE:5246109), complete cds. AK226165 - Homo sapiens mRNA for ubiquitin-conjugating enzyme E2L 6 isoform 1 variant, clone: bm01123. JD357689 - Sequence 338713 from Patent EP1572962. JD385415 - Sequence 366439 from Patent EP1572962. JD491767 - Sequence 472791 from Patent EP1572962. JD296662 - Sequence 277686 from Patent EP1572962. JD177289 - Sequence 158313 from Patent EP1572962. JD445732 - Sequence 426756 from Patent EP1572962. JD073506 - Sequence 54530 from Patent EP1572962. JD078520 - Sequence 59544 from Patent EP1572962. JD331250 - Sequence 312274 from Patent EP1572962. JD284865 - Sequence 265889 from Patent EP1572962. JD045407 - Sequence 26431 from Patent EP1572962. JD229400 - Sequence 210424 from Patent EP1572962. JD099867 - Sequence 80891 from Patent EP1572962. JD374576 - Sequence 355600 from Patent EP1572962. JD051156 - Sequence 32180 from Patent EP1572962. JD324670 - Sequence 305694 from Patent EP1572962. JD142312 - Sequence 123336 from Patent EP1572962. AF031141 - Homo sapiens ubiquitin conjugating enzyme (UbcH8) mRNA, complete cds. CR457126 - Homo sapiens full open reading frame cDNA clone RZPDo834F107D for gene UBE2L6, ubiquitin-conjugating enzyme E2L 6; complete cds, incl. stopcodon. AK315755 - Homo sapiens cDNA, FLJ96866, Homo sapiens ubiquitin-conjugating enzyme E2L 6 (UBE2L6), mRNA. DQ891291 - Synthetic construct clone IMAGE:100003921; FLH170793.01X; RZPDo839B08100D ubiquitin-conjugating enzyme E2L 6 (UBE2L6) gene, encodes complete protein. KJ892727 - Synthetic construct Homo sapiens clone ccsbBroadEn_02121 UBE2L6 gene, encodes complete protein. DQ894475 - Synthetic construct Homo sapiens clone IMAGE:100008935; FLH170789.01L; RZPDo839B0899D ubiquitin-conjugating enzyme E2L 6 (UBE2L6) gene, encodes complete protein. CU689396 - Synthetic construct Homo sapiens gateway clone IMAGE:100016709 5' read UBE2L6 mRNA.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein O14933 (Reactome details) participates in the following event(s):
R-HSA-1169404 Transfer of ISG15 from E1 to E2 (UBCH8) R-HSA-1169394 ISGylation of IRF3 R-HSA-1169395 ISGylation of viral protein NS1 R-HSA-1169398 ISGylation of host protein filamin B R-HSA-1169402 ISGylation of E2 conjugating enzymes R-HSA-1169405 ISGylation of protein phosphatase 1 beta (PP2CB) R-HSA-1169406 ISGylation of host proteins R-HSA-1169403 Interaction of E3 ligase with ISG15:E2 complex R-HSA-5660753 SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-5653756 TRIM25 binds monoUb:164-PCNA R-HSA-5653754 UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA R-HSA-1678843 ISGylation of protein translation regulator 4EHP R-HSA-5658496 SIAH1:UBE2L6:Ubiquitin binds SNCA R-HSA-936563 ISGylation of DDX58 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP R-HSA-1169408 ISG15 antiviral mechanism R-HSA-977225 Amyloid fiber formation R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-392499 Metabolism of proteins R-HSA-5656169 Termination of translesion DNA synthesis R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-913531 Interferon Signaling R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-168249 Innate Immune System R-HSA-1280218 Adaptive Immune System R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-73893 DNA Damage Bypass R-HSA-168256 Immune System R-HSA-73894 DNA Repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
