Human Gene TXNDC5 (ENST00000379757.9_7) from GENCODE V47lift37

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Description: thioredoxin domain containing 5, transcript variant 1 (from RefSeq NM_030810.5)
Gencode Transcript: ENST00000379757.9_7
Gencode Gene: ENSG00000239264.9_10
Transcript (Including UTRs)
Position: hg19 chr6:7,881,750-7,911,021 Size: 29,272 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr6:7,883,377-7,911,009 Size: 27,633 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:7,881,750-7,911,021)			mRNA (may differ from genome)		Protein (432 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TXND5_HUMAN DESCRIPTION: RecName: Full=Thioredoxin domain-containing protein 5; AltName: Full=Endoplasmic reticulum resident protein 46; Short=ER protein 46; Short=ERp46; AltName: Full=Thioredoxin-like protein p46; Flags: Precursor; FUNCTION: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity). SIMILARITY: Belongs to the protein disulfide isomerase family. SIMILARITY: Contains 3 thioredoxin domains. SEQUENCE CAUTION: Sequence=AAH01199.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane D000082 Acetaminophen D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D016572 Cyclosporine D004237 Diuron D007545 Isoproterenol D037742 Nanotubes, Carbon D009569 Nitric Oxide D010100 Oxygen more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 23.04 RPKM in Cells - Cultured fibroblasts Total median expression: 273.22 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-482.00	1627	-0.296	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005788 - Disulphide_isomerase
IPR005746 - Thioredoxin
IPR012336 - Thioredoxin-like_fold
IPR017937 - Thioredoxin_CS
IPR013766 - Thioredoxin_domain

Pfam Domains:
PF00085 - Thioredoxin

SCOP Domains:
50129 - GroES-like
52833 - Thioredoxin-like
57716 - Glucocorticoid receptor-like (DNA-binding domain)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DIZ - NMR MuPIT

3UVT - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q8NBS9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003756 protein disulfide isomerase activity GO:0005515 protein binding GO:0016853 isomerase activity Biological Process: GO:0006457 protein folding GO:0034976 response to endoplasmic reticulum stress GO:0043066 negative regulation of apoptotic process GO:0043277 apoptotic cell clearance GO:0043312 neutrophil degranulation GO:0045454 cell redox homeostasis Cellular Component: GO:0005576 extracellular region GO:0005783 endoplasmic reticulum GO:0005788 endoplasmic reticulum lumen GO:0035578 azurophil granule lumen GO:0043202 lysosomal lumen GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BC052310 - Homo sapiens thioredoxin domain containing 5 (endoplasmic reticulum), mRNA (cDNA clone MGC:59718 IMAGE:6671945), complete cds. KJ901131 - Synthetic construct Homo sapiens clone ccsbBroadEn_10525 TXNDC5 gene, encodes complete protein. CU690906 - Synthetic construct Homo sapiens gateway clone IMAGE:100022387 5' read TXNDC5 mRNA. AY326464 - Homo sapiens putative protein STRF8 (STRF8) mRNA, complete cds. LF209758 - JP 2014500723-A/17261: Polycomb-Associated Non-Coding RNAs. BC003529 - Homo sapiens cDNA clone IMAGE:3608717, partial cds. AK025006 - Homo sapiens cDNA: FLJ21353 fis, clone COL02771. BC001199 - Homo sapiens thioredoxin domain containing 5 (endoplasmic reticulum), mRNA (cDNA clone MGC:3178 IMAGE:3356029), complete cds. GQ891501 - Homo sapiens clone HEL-S-222 epididymis secretory sperm binding protein mRNA, complete cds. AL833008 - Homo sapiens mRNA; cDNA DKFZp666I134 (from clone DKFZp666I134). AY358646 - Homo sapiens clone DNA46776 disulfide isomerase (UNQ364) mRNA, complete cds. AL834423 - Homo sapiens mRNA; cDNA DKFZp667E126 (from clone DKFZp667E126). AK075291 - Homo sapiens cDNA FLJ90810 fis, clone Y79AA1000876, weakly similar to PROTEIN DISULFIDE ISOMERASE-RELATED PROTEIN PRECURSOR. AK098089 - Homo sapiens cDNA FLJ40770 fis, clone TRACH2004183, weakly similar to Aedes triseriatus disulfide-isomerase mRNA. LF331477 - JP 2014500723-A/138980: Polycomb-Associated Non-Coding RNAs. JD080597 - Sequence 61621 from Patent EP1572962. JD036796 - Sequence 17820 from Patent EP1572962. JD454773 - Sequence 435797 from Patent EP1572962. LF331478 - JP 2014500723-A/138981: Polycomb-Associated Non-Coding RNAs. JD439076 - Sequence 420100 from Patent EP1572962. JD039696 - Sequence 20720 from Patent EP1572962. JD498579 - Sequence 479603 from Patent EP1572962. JD037899 - Sequence 18923 from Patent EP1572962. LF331479 - JP 2014500723-A/138982: Polycomb-Associated Non-Coding RNAs. JD488336 - Sequence 469360 from Patent EP1572962. JD268376 - Sequence 249400 from Patent EP1572962. JD181580 - Sequence 162604 from Patent EP1572962. JD544754 - Sequence 525778 from Patent EP1572962. JD297580 - Sequence 278604 from Patent EP1572962. JD251310 - Sequence 232334 from Patent EP1572962. JD225568 - Sequence 206592 from Patent EP1572962. JD289866 - Sequence 270890 from Patent EP1572962. JD061334 - Sequence 42358 from Patent EP1572962. LF331480 - JP 2014500723-A/138983: Polycomb-Associated Non-Coding RNAs. DQ580398 - Homo sapiens piRNA piR-48510, complete sequence. DQ580397 - Homo sapiens piRNA piR-48509, complete sequence. JD140866 - Sequence 121890 from Patent EP1572962. JD394425 - Sequence 375449 from Patent EP1572962. JD503188 - Sequence 484212 from Patent EP1572962. JD150973 - Sequence 131997 from Patent EP1572962. DQ578913 - Homo sapiens piRNA piR-47025, complete sequence. LF331481 - JP 2014500723-A/138984: Polycomb-Associated Non-Coding RNAs. AK315598 - Homo sapiens cDNA, FLJ96678, Homo sapiens thioredoxin domain containing 5 (TXNDC5), mRNA. AJ440721 - Homo sapiens mRNA for thioredoxin related protein. LF331482 - JP 2014500723-A/138985: Polycomb-Associated Non-Coding RNAs. LF331483 - JP 2014500723-A/138986: Polycomb-Associated Non-Coding RNAs. LF331485 - JP 2014500723-A/138988: Polycomb-Associated Non-Coding RNAs. LF331487 - JP 2014500723-A/138990: Polycomb-Associated Non-Coding RNAs. LF331488 - JP 2014500723-A/138991: Polycomb-Associated Non-Coding RNAs. LF331490 - JP 2014500723-A/138993: Polycomb-Associated Non-Coding RNAs. LF331493 - JP 2014500723-A/138996: Polycomb-Associated Non-Coding RNAs. AK129666 - Homo sapiens cDNA FLJ26155 fis, clone ADG01203. LF331498 - JP 2014500723-A/139001: Polycomb-Associated Non-Coding RNAs. LF331502 - JP 2014500723-A/139005: Polycomb-Associated Non-Coding RNAs. JD094256 - Sequence 75280 from Patent EP1572962. JD393566 - Sequence 374590 from Patent EP1572962. MA567054 - JP 2018138019-A/138980: Polycomb-Associated Non-Coding RNAs. MA567055 - JP 2018138019-A/138981: Polycomb-Associated Non-Coding RNAs. MA567056 - JP 2018138019-A/138982: Polycomb-Associated Non-Coding RNAs. MA567057 - JP 2018138019-A/138983: Polycomb-Associated Non-Coding RNAs. MA567058 - JP 2018138019-A/138984: Polycomb-Associated Non-Coding RNAs. MA567059 - JP 2018138019-A/138985: Polycomb-Associated Non-Coding RNAs. MA567060 - JP 2018138019-A/138986: Polycomb-Associated Non-Coding RNAs. MA567062 - JP 2018138019-A/138988: Polycomb-Associated Non-Coding RNAs. MA567064 - JP 2018138019-A/138990: Polycomb-Associated Non-Coding RNAs. MA567065 - JP 2018138019-A/138991: Polycomb-Associated Non-Coding RNAs. MA567067 - JP 2018138019-A/138993: Polycomb-Associated Non-Coding RNAs. MA567070 - JP 2018138019-A/138996: Polycomb-Associated Non-Coding RNAs. MA567075 - JP 2018138019-A/139001: Polycomb-Associated Non-Coding RNAs. MA567079 - JP 2018138019-A/139005: Polycomb-Associated Non-Coding RNAs. MA445335 - JP 2018138019-A/17261: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q8NBS9 (Reactome details) participates in the following event(s): R-HSA-429815 Formation Of Bloc-1 Complex R-HSA-432688 trans-Golgi Network Derived Lysosomal Vesicle Uncoating R-HSA-432712 Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane R-HSA-6798751 Exocytosis of azurophil granule lumen proteins R-HSA-432707 trans-Golgi Network Lysosomal Vesicle Scission R-HSA-432706 trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly R-HSA-432722 Golgi Associated Vesicle Biogenesis R-HSA-432720 Lysosome Vesicle Biogenesis R-HSA-421837 Clathrin derived vesicle budding R-HSA-6798695 Neutrophil degranulation R-HSA-199992 trans-Golgi Network Vesicle Budding R-HSA-168249 Innate Immune System R-HSA-199991 Membrane Trafficking R-HSA-168256 Immune System R-HSA-5653656 Vesicle-mediated transport

Other Names for This Gene


	Alternate Gene Symbols: B2RDM2, ENST00000379757.1, ENST00000379757.2, ENST00000379757.3, ENST00000379757.4, ENST00000379757.5, ENST00000379757.6, ENST00000379757.7, ENST00000379757.8, NM_030810, Q5TCQ0, Q8NBS9, Q8ND33, Q8TCT2, Q9BVH9, TLP46, TXND5_HUMAN, TXNDC5 , uc318pef.1, uc318pef.2, UNQ364/PRO700 UCSC ID: ENST00000379757.9_7 RefSeq Accession: NM_030810.5 Protein: Q8NBS9 (aka TXND5_HUMAN or TXN5_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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