Human Gene TXLNB (ENST00000358430.8_8) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: taxilin beta (from RefSeq NM_153235.4)
Gencode Transcript: ENST00000358430.8_8
Gencode Gene: ENSG00000164440.16_14
Transcript (Including UTRs)
Position: hg19 chr6:139,561,198-139,613,135 Size: 51,938 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr6:139,563,663-139,610,036 Size: 46,374 Coding Exon Count: 9

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:139,561,198-139,613,135)			mRNA (may differ from genome)		Protein (684 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TXLNB_HUMAN DESCRIPTION: RecName: Full=Beta-taxilin; AltName: Full=Muscle-derived protein 77; Short=hMDP77; FUNCTION: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. SUBUNIT: Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A. INTERACTION: P40222:TXLNA; NbExp=2; IntAct=EBI-6116822, EBI-359793; TISSUE SPECIFICITY: Expressed in skeletal muscle. SIMILARITY: Belongs to the taxilin family. SEQUENCE CAUTION: Sequence=CAD38924.2; Type=Erroneous initiation; Sequence=CAD91140.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TXLNB Diseases sorted by gene-association score: myotonic disease (5), myotonic dystrophy 1 (5)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D000082 Acetaminophen D018817 N-Methyl-3,4-methylenedioxyamphetamine D014028 Tobacco Smoke Pollution

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 60.18 RPKM in Muscle - Skeletal Total median expression: 126.67 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-9.40	92	-0.102	Picture	PostScript	Text
3' UTR	-605.90	2465	-0.246	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026183 - Taxilin_fam

Pfam Domains:
PF09728 - Myosin-like coiled-coil protein

SCOP Domains:
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q8N3L3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0019905 syntaxin binding Cellular Component: GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AL832322 - Homo sapiens mRNA; cDNA DKFZp451A175 (from clone DKFZp451A175). BX647633 - Homo sapiens mRNA; cDNA DKFZp451B226 (from clone DKFZp451B226). AL831988 - Homo sapiens mRNA; cDNA DKFZp451G083 (from clone DKFZp451G083). BX647477 - Homo sapiens mRNA; cDNA DKFZp451H216 (from clone DKFZp451H216). AL834248 - Homo sapiens mRNA; cDNA DKFZp451F022 (from clone DKFZp451F022); complete cds. BC115383 - Homo sapiens taxilin beta, mRNA (cDNA clone MGC:134825 IMAGE:40038091), complete cds. BC115384 - Homo sapiens taxilin beta, mRNA (cDNA clone MGC:134826 IMAGE:40038098), complete cds. AB085905 - Homo sapiens hMDP77 mRNA for muscle-derived protein 77, complete cds. AK314725 - Homo sapiens cDNA, FLJ95585. KJ900378 - Synthetic construct Homo sapiens clone ccsbBroadEn_09772 TXLNB gene, encodes complete protein. AB527233 - Synthetic construct DNA, clone: pF1KE0307, Homo sapiens TXLNB gene for taxilin beta, without stop codon, in Flexi system. AM392784 - Synthetic construct Homo sapiens clone IMAGE:100002192 for hypothetical protein (TXLNB gene). AM393407 - Synthetic construct Homo sapiens clone IMAGE:100002163 for hypothetical protein (TXLNB gene). AM393849 - Synthetic construct Homo sapiens clone IMAGE:100002191 for hypothetical protein (TXLNB gene). AF111704 - Homo sapiens SLTP001 (LST001) mRNA, complete cds. JD303557 - Sequence 284581 from Patent EP1572962. JD328236 - Sequence 309260 from Patent EP1572962. JD440068 - Sequence 421092 from Patent EP1572962. JD507911 - Sequence 488935 from Patent EP1572962. JD046959 - Sequence 27983 from Patent EP1572962. AK056970 - Homo sapiens cDNA FLJ32408 fis, clone SKMUS2000467. JD273729 - Sequence 254753 from Patent EP1572962. JD358385 - Sequence 339409 from Patent EP1572962. JD472782 - Sequence 453806 from Patent EP1572962. JD436278 - Sequence 417302 from Patent EP1572962. JD434292 - Sequence 415316 from Patent EP1572962. JD305745 - Sequence 286769 from Patent EP1572962. JD207812 - Sequence 188836 from Patent EP1572962. JD304627 - Sequence 285651 from Patent EP1572962. JD039743 - Sequence 20767 from Patent EP1572962. JD445293 - Sequence 426317 from Patent EP1572962. JD151408 - Sequence 132432 from Patent EP1572962. JD311046 - Sequence 292070 from Patent EP1572962. JD410160 - Sequence 391184 from Patent EP1572962. JD259917 - Sequence 240941 from Patent EP1572962. JD250269 - Sequence 231293 from Patent EP1572962. JD551617 - Sequence 532641 from Patent EP1572962. JD182410 - Sequence 163434 from Patent EP1572962. JD507669 - Sequence 488693 from Patent EP1572962. JD090959 - Sequence 71983 from Patent EP1572962. JD050612 - Sequence 31636 from Patent EP1572962. JD562993 - Sequence 544017 from Patent EP1572962. JD076837 - Sequence 57861 from Patent EP1572962. JD201204 - Sequence 182228 from Patent EP1572962. JD099286 - Sequence 80310 from Patent EP1572962. JD459830 - Sequence 440854 from Patent EP1572962. JD120907 - Sequence 101931 from Patent EP1572962. JD151397 - Sequence 132421 from Patent EP1572962. JD297923 - Sequence 278947 from Patent EP1572962. JD202474 - Sequence 183498 from Patent EP1572962. JD265564 - Sequence 246588 from Patent EP1572962. JD428476 - Sequence 409500 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: C6orf198, ENST00000358430.1, ENST00000358430.2, ENST00000358430.3, ENST00000358430.4, ENST00000358430.5, ENST00000358430.6, ENST00000358430.7, MDP77, NM_153235, Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2, TXLNB_HUMAN, uc318any.1, uc318any.2 UCSC ID: ENST00000358430.8_8 RefSeq Accession: NM_153235.4 Protein: Q8N3L3 (aka TXLNB_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.