Human Gene TSC22D4 (ENST00000300181.7_10) from GENCODE V47lift37

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Description: TSC22 domain family member 4, transcript variant 1 (from RefSeq NM_030935.5)
Gencode Transcript: ENST00000300181.7_10
Gencode Gene: ENSG00000166925.9_15
Transcript (Including UTRs)
Position: hg19 chr7:100,064,142-100,076,837 Size: 12,696 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr7:100,064,582-100,075,661 Size: 11,080 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:100,064,142-100,076,837)			mRNA (may differ from genome)		Protein (395 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: T22D4_HUMAN DESCRIPTION: RecName: Full=TSC22 domain family protein 4; AltName: Full=TSC22-related-inducible leucine zipper protein 2; AltName: Full=Tsc-22-like protein THG-1; FUNCTION: Transcriptional repressor. SUBUNIT: Forms homodimer or heterodimer. Can form a heterodimer with TSC22D1. INTERACTION: O95831:AIFM1; NbExp=2; IntAct=EBI-739485, EBI-356440; Q14145:KEAP1; NbExp=3; IntAct=EBI-739485, EBI-751001; Q15365:PCBP1; NbExp=2; IntAct=EBI-739485, EBI-946095; P84022:SMAD3; NbExp=2; IntAct=EBI-739485, EBI-347161; O75800:ZMYND10; NbExp=2; IntAct=EBI-739485, EBI-747061; SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the TSC-22/Dip/Bun family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D005485 Flutamide D007545 Isoproterenol D010795 Phthalic Acids D012645 Selenomethionine D013749 Tetrachlorodibenzodioxin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 141.40 RPKM in Brain - Substantia nigra Total median expression: 2217.25 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-294.60	690	-0.427	Picture	PostScript	Text
3' UTR	-176.00	440	-0.400	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000580 - TSC-22_Dip_Bun

Pfam Domains:
PF01166 - TSC-22/dip/bun family

SCOP Domains:
58026 - Delta-sleep-inducing peptide immunoreactive peptide

ModBase Predicted Comparative 3D Structure on Q9Y3Q8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045892 negative regulation of transcription, DNA-templated GO:0070236 negative regulation of activation-induced cell death of T cells Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	BC011974 - Homo sapiens cDNA clone IMAGE:4154342, containing frame-shift errors. AJ133115 - Homo sapiens mRNA for TSC-22-like protein. BC001966 - Homo sapiens TSC22 domain family, member 4, mRNA (cDNA clone MGC:5035 IMAGE:3457297), complete cds. BC001486 - Homo sapiens TSC22 domain family, member 4, mRNA (cDNA clone MGC:1424 IMAGE:2966929), complete cds. BC010406 - Homo sapiens TSC22 domain family, member 4, mRNA (cDNA clone MGC:15250 IMAGE:3832780), complete cds. BC002972 - Homo sapiens TSC22 domain family, member 4, mRNA (cDNA clone MGC:1941 IMAGE:3538175), complete cds. JD353611 - Sequence 334635 from Patent EP1572962. JD394190 - Sequence 375214 from Patent EP1572962. JD520088 - Sequence 501112 from Patent EP1572962. AK297702 - Homo sapiens cDNA FLJ57331 complete cds, highly similar to TSC22 domain family protein 4. JD355220 - Sequence 336244 from Patent EP1572962. JD403017 - Sequence 384041 from Patent EP1572962. JD394940 - Sequence 375964 from Patent EP1572962. JD191588 - Sequence 172612 from Patent EP1572962. JD541692 - Sequence 522716 from Patent EP1572962. JD191130 - Sequence 172154 from Patent EP1572962. JD129307 - Sequence 110331 from Patent EP1572962. JD476977 - Sequence 458001 from Patent EP1572962. JD398299 - Sequence 379323 from Patent EP1572962. JD423117 - Sequence 404141 from Patent EP1572962. AK314824 - Homo sapiens cDNA, FLJ95703. KJ894857 - Synthetic construct Homo sapiens clone ccsbBroadEn_04251 TSC22D4 gene, encodes complete protein. KJ906341 - Synthetic construct Homo sapiens clone ccsbBroadEn_16011 TSC22D4 gene, encodes complete protein. KJ906342 - Synthetic construct Homo sapiens clone ccsbBroadEn_16012 TSC22D4 gene, encodes complete protein. DQ891268 - Synthetic construct clone IMAGE:100003898; FLH170593.01X; RZPDo839H0298D TSC22 domain family, member 4 (TSC22D4) gene, encodes complete protein. EU176567 - Synthetic construct Homo sapiens clone IMAGE:100011384; FLH170592.01L; RZPDo839H11253D TSC22 domain family, member 4 (TSC22D4) gene, encodes complete protein. AB464322 - Synthetic construct DNA, clone: pF1KB7660, Homo sapiens TSC22D4 gene for TSC22 domain family, member 4, without stop codon, in Flexi system. AK296580 - Homo sapiens cDNA FLJ52209 complete cds. BC031622 - Homo sapiens TSC22 domain family, member 4, mRNA (cDNA clone MGC:35267 IMAGE:5174360), complete cds. CU679701 - Synthetic construct Homo sapiens gateway clone IMAGE:100017173 5' read TSC22D4 mRNA. CU674964 - Synthetic construct Homo sapiens gateway clone IMAGE:100017176 5' read TSC22D4 mRNA. AK310800 - Homo sapiens cDNA, FLJ17842. JD394350 - Sequence 375374 from Patent EP1572962. JD210355 - Sequence 191379 from Patent EP1572962. JD547194 - Sequence 528218 from Patent EP1572962. JD455391 - Sequence 436415 from Patent EP1572962. JD128594 - Sequence 109618 from Patent EP1572962. JD124685 - Sequence 105709 from Patent EP1572962. JD518906 - Sequence 499930 from Patent EP1572962. JD414605 - Sequence 395629 from Patent EP1572962. JD152585 - Sequence 133609 from Patent EP1572962. JD373267 - Sequence 354291 from Patent EP1572962. JD191198 - Sequence 172222 from Patent EP1572962. JD399977 - Sequence 381001 from Patent EP1572962. JD400870 - Sequence 381894 from Patent EP1572962. JD248301 - Sequence 229325 from Patent EP1572962. JD218100 - Sequence 199124 from Patent EP1572962. JD214864 - Sequence 195888 from Patent EP1572962. JD381947 - Sequence 362971 from Patent EP1572962. JD317447 - Sequence 298471 from Patent EP1572962. JD295646 - Sequence 276670 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A4D2C3, A8MWR6, D6W5V9, ENST00000300181.1, ENST00000300181.2, ENST00000300181.3, ENST00000300181.4, ENST00000300181.5, ENST00000300181.6, NM_030935, Q9Y3Q8, T22D4_HUMAN, THG1 , THG1-PIT , TSC22D4 , uc317moh.1, uc317moh.2 UCSC ID: ENST00000300181.7_10 RefSeq Accession: NM_030935.5 Protein: Q9Y3Q8 (aka T22D4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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