ID:TRPC5_HUMAN DESCRIPTION: RecName: Full=Short transient receptor potential channel 5; Short=TrpC5; AltName: Full=Transient receptor protein 5; Short=TRP-5; Short=hTRP-5; Short=hTRP5; FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. ENZYME REGULATION: Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane. SUBUNIT: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C- terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. SIMILARITY: Contains 4 ANK repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UL62
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0006828 manganese ion transport GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007399 nervous system development GO:0008284 positive regulation of cell proliferation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0030182 neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0045773 positive regulation of axon extension GO:0050774 negative regulation of dendrite morphogenesis GO:0051480 regulation of cytosolic calcium ion concentration GO:0055085 transmembrane transport GO:0070588 calcium ion transmembrane transport GO:1902630 regulation of membrane hyperpolarization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
