Human Gene TOMM40L (ENST00000367987.1_2) from GENCODE V47lift37

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Description: Potential channel-forming protein implicated in import of protein precursors into mitochondria. (from UniProt Q969M1)
Gencode Transcript: ENST00000367987.1_2
Gencode Gene: ENSG00000158882.15_8
Transcript (Including UTRs)
Position: hg19 chr1:161,196,094-161,200,408 Size: 4,315 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr1:161,196,280-161,198,885 Size: 2,606 Coding Exon Count: 9

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:161,196,094-161,200,408)			mRNA (may differ from genome)		Protein (308 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
MGI	PubMed	UniProtKB	Wikipedia

Comments and Description Text from UniProtKB


	ID: TM40L_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import receptor subunit TOM40B; AltName: Full=Protein TOMM40-like; FUNCTION: Potential channel-forming protein implicated in import of protein precursors into mitochondria (By similarity). SUBUNIT: Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the Tom40 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D003300 Copper D019327 Copper Sulfate D003993 Dibutyl Phthalate D004051 Diethylhexyl Phthalate C558013 NSC 689534 D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin C006780 bisphenol A C039281 furan more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 5.49 RPKM in Heart - Left Ventricle Total median expression: 142.40 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-66.80	186	-0.359	Picture	PostScript	Text
3' UTR	-551.40	1523	-0.362	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001925 - Porin_Euk

Pfam Domains:
PF01459 - Eukaryotic porin

ModBase Predicted Comparative 3D Structure on Q969M1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details				Gene Details
Gene Sorter	Gene Sorter				Gene Sorter
	RGD				SGD
					Protein Sequence
					Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0008320 protein transmembrane transporter activity GO:0015288 porin activity GO:0030943 mitochondrion targeting sequence binding GO:0070678 preprotein binding Biological Process: GO:0006811 ion transport GO:0008150 biological_process GO:0015031 protein transport GO:0030150 protein import into mitochondrial matrix GO:0055085 transmembrane transport Cellular Component: GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0005742 mitochondrial outer membrane translocase complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0032991 macromolecular complex GO:0046930 pore complex

Descriptions from all associated GenBank mRNAs


	AK297848 - Homo sapiens cDNA FLJ52571 complete cds, highly similar to Protein TOMM40-like. AK027704 - Homo sapiens cDNA FLJ14798 fis, clone NT2RP4001313, weakly similar to MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40. AK022832 - Homo sapiens cDNA FLJ12770 fis, clone NT2RP2001613, weakly similar to MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40. BX537951 - Homo sapiens mRNA; cDNA DKFZp686I2086 (from clone DKFZp686I2086); complete cds. AK297831 - Homo sapiens cDNA FLJ52528 complete cds, highly similar to Protein TOMM40-like. BC014946 - Homo sapiens translocase of outer mitochondrial membrane 40 homolog (yeast)-like, mRNA (cDNA clone MGC:22951 IMAGE:4872309), complete cds. JD523847 - Sequence 504871 from Patent EP1572962. JD152392 - Sequence 133416 from Patent EP1572962. CU677129 - Synthetic construct Homo sapiens gateway clone IMAGE:100023358 5' read TOMM40L mRNA. AB528265 - Synthetic construct DNA, clone: pF1KE0451, Homo sapiens TOMM40L gene for translocase of outer mitochondrial membrane 40 homolog (yeast)-like, without stop codon, in Flexi system. AM392638 - Synthetic construct Homo sapiens clone IMAGE:100002155 for hypothetical protein (TOMM40L gene). AM393089 - Synthetic construct Homo sapiens clone IMAGE:100002154 for hypothetical protein (TOMM40L gene). KJ894940 - Synthetic construct Homo sapiens clone ccsbBroadEn_04334 TOMM40L gene, encodes complete protein. JD260454 - Sequence 241478 from Patent EP1572962. JD273067 - Sequence 254091 from Patent EP1572962. JD435666 - Sequence 416690 from Patent EP1572962. JD392238 - Sequence 373262 from Patent EP1572962. JD345946 - Sequence 326970 from Patent EP1572962. JD498000 - Sequence 479024 from Patent EP1572962. JD108173 - Sequence 89197 from Patent EP1572962. JD508721 - Sequence 489745 from Patent EP1572962. JD338478 - Sequence 319502 from Patent EP1572962. JD199105 - Sequence 180129 from Patent EP1572962. JD387033 - Sequence 368057 from Patent EP1572962. JD387034 - Sequence 368058 from Patent EP1572962. JD183252 - Sequence 164276 from Patent EP1572962. JD228282 - Sequence 209306 from Patent EP1572962. JD386835 - Sequence 367859 from Patent EP1572962. JD528437 - Sequence 509461 from Patent EP1572962. JD297851 - Sequence 278875 from Patent EP1572962. JD254147 - Sequence 235171 from Patent EP1572962. JD521494 - Sequence 502518 from Patent EP1572962. JD559755 - Sequence 540779 from Patent EP1572962. JD125304 - Sequence 106328 from Patent EP1572962. JD142203 - Sequence 123227 from Patent EP1572962. JD383268 - Sequence 364292 from Patent EP1572962. JD385310 - Sequence 366334 from Patent EP1572962. JD109259 - Sequence 90283 from Patent EP1572962. JD510293 - Sequence 491317 from Patent EP1572962. JD374135 - Sequence 355159 from Patent EP1572962. JD221575 - Sequence 202599 from Patent EP1572962. JD355572 - Sequence 336596 from Patent EP1572962. CU686947 - Synthetic construct Homo sapiens gateway clone IMAGE:100022636 3' read NR1I3 mRNA. JD199964 - Sequence 180988 from Patent EP1572962. JD151117 - Sequence 132141 from Patent EP1572962. JD330495 - Sequence 311519 from Patent EP1572962. JD271979 - Sequence 253003 from Patent EP1572962. JD045888 - Sequence 26912 from Patent EP1572962. JD409519 - Sequence 390543 from Patent EP1572962. JD443453 - Sequence 424477 from Patent EP1572962. JD275895 - Sequence 256919 from Patent EP1572962. JD250907 - Sequence 231931 from Patent EP1572962. JD068837 - Sequence 49861 from Patent EP1572962. JD304762 - Sequence 285786 from Patent EP1572962. JD276605 - Sequence 257629 from Patent EP1572962. JD214061 - Sequence 195085 from Patent EP1572962. JD047982 - Sequence 29006 from Patent EP1572962. JD178140 - Sequence 159164 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B7Z4U0, BC014946, D3DVG9, Q969M1, TM40L_HUMAN, TOMM40B, uc318gjf.1, uc318gjf.2 UCSC ID: ENST00000367987.1_2 RefSeq Accession: NM_032174.6 Protein: Q969M1 (aka TM40L_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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