Human Gene TMEM71 (ENST00000677595.1_7) from GENCODE V47lift37
  Description: transmembrane protein 71, transcript variant 13 (from RefSeq NM_001382405.1)
Gencode Transcript: ENST00000677595.1_7
Gencode Gene: ENSG00000165071.15_19
Transcript (Including UTRs)
   Position: hg19 chr8:133,722,187-133,772,828 Size: 50,642 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr8:133,723,213-133,771,125 Size: 47,913 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:133,722,187-133,772,828)mRNA (may differ from genome)Protein (295 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMM71_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 71;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM71 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.20143-0.232 Picture PostScript Text
3' UTR -231.501026-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15121 - TMEM71 protein family

ModBase Predicted Comparative 3D Structure on Q6P5X7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC062592 - Homo sapiens transmembrane protein 71, mRNA (cDNA clone MGC:74618 IMAGE:5224669), complete cds.
BC105783 - Homo sapiens transmembrane protein 71, mRNA (cDNA clone MGC:111188 IMAGE:4669222), complete cds.
BC022053 - Homo sapiens transmembrane protein 71, mRNA (cDNA clone IMAGE:4663927), partial cds.
AK057631 - Homo sapiens cDNA FLJ33069 fis, clone TRACH2000196.
JD222275 - Sequence 203299 from Patent EP1572962.
JD412469 - Sequence 393493 from Patent EP1572962.
JD348698 - Sequence 329722 from Patent EP1572962.
JD316475 - Sequence 297499 from Patent EP1572962.
JD182226 - Sequence 163250 from Patent EP1572962.
JD263662 - Sequence 244686 from Patent EP1572962.
JD304273 - Sequence 285297 from Patent EP1572962.
JD559745 - Sequence 540769 from Patent EP1572962.
JD534584 - Sequence 515608 from Patent EP1572962.
KJ895517 - Synthetic construct Homo sapiens clone ccsbBroadEn_04911 TMEM71 gene, encodes complete protein.
JD162099 - Sequence 143123 from Patent EP1572962.
JD363483 - Sequence 344507 from Patent EP1572962.
JD042032 - Sequence 23056 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001382405, Q3KRC2, Q6P5X7, Q8WVZ4, Q96LX9, TMM71_HUMAN, uc330cvg.1, uc330cvg.2
UCSC ID: ENST00000677595.1_7
RefSeq Accession: NM_001382403.1
Protein: Q6P5X7 (aka TMM71_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.