Human Gene TMEM64 (ENST00000458549.7_7) from GENCODE V47lift37

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Description: transmembrane protein 64, transcript variant 1 (from RefSeq NM_001008495.4)
Gencode Transcript: ENST00000458549.7_7
Gencode Gene: ENSG00000180694.14_10
Transcript (Including UTRs)
Position: hg19 chr8:91,634,228-91,658,311 Size: 24,084 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr8:91,637,899-91,658,133 Size: 20,235 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:91,634,228-91,658,311)			mRNA (may differ from genome)		Protein (380 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TMM64_HUMAN DESCRIPTION: RecName: Full=Transmembrane protein 64; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the TVP38/TMEM64 family. SEQUENCE CAUTION: Sequence=AAN05737.1; Type=Erroneous initiation; Sequence=CAD39028.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D000082 Acetaminophen D003375 Coumestrol D016572 Cyclosporine D004958 Estradiol C523799 MRK 003 D011794 Quercetin D014212 Tretinoin D014640 Vancomycin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 8.27 RPKM in Thyroid Total median expression: 220.28 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-95.30	178	-0.535	Picture	PostScript	Text
3' UTR	-825.50	3671	-0.225	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR015414 - SNARE_assoc

Pfam Domains:
PF09335 - SNARE associated Golgi protein

ModBase Predicted Comparative 3D Structure on Q6YI46


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0043462 regulation of ATPase activity GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045672 positive regulation of osteoclast differentiation GO:0045780 positive regulation of bone resorption GO:0051480 regulation of cytosolic calcium ion concentration GO:0090090 negative regulation of canonical Wnt signaling pathway Cellular Component: GO:0005783 endoplasmic reticulum GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	LF206394 - JP 2014500723-A/13897: Polycomb-Associated Non-Coding RNAs. BC113828 - Homo sapiens transmembrane protein 64, mRNA (cDNA clone IMAGE:40024272), complete cds. MA441971 - JP 2018138019-A/13897: Polycomb-Associated Non-Coding RNAs. AK095472 - Homo sapiens cDNA FLJ38153 fis, clone DFNES1000083. LF353904 - JP 2014500723-A/161407: Polycomb-Associated Non-Coding RNAs. LF353902 - JP 2014500723-A/161405: Polycomb-Associated Non-Coding RNAs. AL834364 - Homo sapiens mRNA; cDNA DKFZp762C1112 (from clone DKFZp762C1112). BC017409 - Homo sapiens transmembrane protein 64, mRNA (cDNA clone IMAGE:4332938). AK123958 - Homo sapiens cDNA FLJ41964 fis, clone PUAEN2006701, highly similar to Homo sapiens transmembrane protein 64 (TMEM64), mRNA. LF353899 - JP 2014500723-A/161402: Polycomb-Associated Non-Coding RNAs. JD352217 - Sequence 333241 from Patent EP1572962. LF353898 - JP 2014500723-A/161401: Polycomb-Associated Non-Coding RNAs. JD022171 - Sequence 3195 from Patent EP1572962. JD032095 - Sequence 13119 from Patent EP1572962. JD024498 - Sequence 5522 from Patent EP1572962. JD033831 - Sequence 14855 from Patent EP1572962. LF353897 - JP 2014500723-A/161400: Polycomb-Associated Non-Coding RNAs. JD285772 - Sequence 266796 from Patent EP1572962. AY147881 - Homo sapiens tissue-type testis chromosome 8 unknown mRNA. JD561852 - Sequence 542876 from Patent EP1572962. AK300583 - Homo sapiens cDNA FLJ50226 complete cds, moderately similar to Homo sapiens transmembrane protein 64 (TMEM64), mRNA. JD194970 - Sequence 175994 from Patent EP1572962. JD543705 - Sequence 524729 from Patent EP1572962. LF353895 - JP 2014500723-A/161398: Polycomb-Associated Non-Coding RNAs. KJ903957 - Synthetic construct Homo sapiens clone ccsbBroadEn_13351 TMEM64 gene, encodes complete protein. LF353892 - JP 2014500723-A/161395: Polycomb-Associated Non-Coding RNAs. LF353891 - JP 2014500723-A/161394: Polycomb-Associated Non-Coding RNAs. LF353876 - JP 2014500723-A/161379: Polycomb-Associated Non-Coding RNAs. LF353875 - JP 2014500723-A/161378: Polycomb-Associated Non-Coding RNAs. JD485788 - Sequence 466812 from Patent EP1572962. JD558085 - Sequence 539109 from Patent EP1572962. JD513278 - Sequence 494302 from Patent EP1572962. JD129704 - Sequence 110728 from Patent EP1572962. JD129078 - Sequence 110102 from Patent EP1572962. JD545890 - Sequence 526914 from Patent EP1572962. JD164363 - Sequence 145387 from Patent EP1572962. JD434573 - Sequence 415597 from Patent EP1572962. LF353874 - JP 2014500723-A/161377: Polycomb-Associated Non-Coding RNAs. MA589481 - JP 2018138019-A/161407: Polycomb-Associated Non-Coding RNAs. MA589479 - JP 2018138019-A/161405: Polycomb-Associated Non-Coding RNAs. MA589476 - JP 2018138019-A/161402: Polycomb-Associated Non-Coding RNAs. MA589475 - JP 2018138019-A/161401: Polycomb-Associated Non-Coding RNAs. MA589474 - JP 2018138019-A/161400: Polycomb-Associated Non-Coding RNAs. MA589472 - JP 2018138019-A/161398: Polycomb-Associated Non-Coding RNAs. MA589469 - JP 2018138019-A/161395: Polycomb-Associated Non-Coding RNAs. MA589468 - JP 2018138019-A/161394: Polycomb-Associated Non-Coding RNAs. MA589453 - JP 2018138019-A/161379: Polycomb-Associated Non-Coding RNAs. MA589452 - JP 2018138019-A/161378: Polycomb-Associated Non-Coding RNAs. MA589451 - JP 2018138019-A/161377: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B4DUC0, ENST00000458549.1, ENST00000458549.2, ENST00000458549.3, ENST00000458549.4, ENST00000458549.5, ENST00000458549.6, F5GXM4, NM_001008495, Q2HIZ7, Q6YI46, Q8N3G6, TMM64_HUMAN, uc320ziu.1, uc320ziu.2 UCSC ID: ENST00000458549.7_7 RefSeq Accession: NM_001008495.4 Protein: Q6YI46 (aka TMM64_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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