Human Gene TMEM238 (ENST00000444469.4_7) from GENCODE V47lift37

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Description: transmembrane protein 238 (from RefSeq NM_001190764.2)
Gencode Transcript: ENST00000444469.4_7
Gencode Gene: ENSG00000233493.4_9
Transcript (Including UTRs)
Position: hg19 chr19:55,890,612-55,895,660 Size: 5,049 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr19:55,895,097-55,895,627 Size: 531 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:55,890,612-55,895,660)			mRNA (may differ from genome)		Protein (176 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TM238_HUMAN DESCRIPTION: RecName: Full=Transmembrane protein 238; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D012999 Soman C006780 bisphenol A

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 5.94 RPKM in Colon - Transverse Total median expression: 59.16 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-13.60	33	-0.412	Picture	PostScript	Text
3' UTR	-27.10	131	-0.207	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF15125 - TMEM238 protein family

ModBase Predicted Comparative 3D Structure on C9JI98


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
		Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC052596 - Homo sapiens hypothetical gene supported by BC052596, mRNA (cDNA clone IMAGE:6728287). JD406576 - Sequence 387600 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: C9JI98, ENST00000444469.1, ENST00000444469.2, ENST00000444469.3, NM_001190764, TM238_HUMAN, uc320min.1, uc320min.2 UCSC ID: ENST00000444469.4_7 RefSeq Accession: NM_001190764.2 Protein: C9JI98 (aka TM238_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.