Human Gene TMEM215 (ENST00000342743.6_4) from GENCODE V47lift37

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Description: transmembrane protein 215 (from RefSeq NM_212558.3)
Gencode Transcript: ENST00000342743.6_4
Gencode Gene: ENSG00000188133.6_7
Transcript (Including UTRs)
Position: hg19 chr9:32,783,538-32,789,199 Size: 5,662 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr9:32,784,182-32,784,889 Size: 708 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:32,783,538-32,789,199)			mRNA (may differ from genome)		Protein (235 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TM215_HUMAN DESCRIPTION: RecName: Full=Transmembrane protein 215; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C547126 AZM551248 D000535 Aluminum D013749 Tetrachlorodibenzodioxin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.38 RPKM in Testis Total median expression: 8.75 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-149.00	324	-0.460	Picture	PostScript	Text
3' UTR	-1010.90	4310	-0.235	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF15746 - TMEM215 family

ModBase Predicted Comparative 3D Structure on Q68D42


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK125320 - Homo sapiens cDNA FLJ43330 fis, clone NT2RI3005403. BX647550 - Homo sapiens mRNA; cDNA DKFZp686N0997 (from clone DKFZp686N0997). CR749589 - Homo sapiens mRNA; cDNA DKFZp686I2292 (from clone DKFZp686I2292).

Other Names for This Gene


	Alternate Gene Symbols: ENST00000342743.1, ENST00000342743.2, ENST00000342743.3, ENST00000342743.4, ENST00000342743.5, NM_212558, Q68D42, Q6ZUU2, TM215_HUMAN, uc317wle.1, uc317wle.2 UCSC ID: ENST00000342743.6_4 RefSeq Accession: NM_212558.3 Protein: Q68D42 (aka TM215_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.