Human Gene TMEM196 (ENST00000405764.7_9) from GENCODE V47lift37
  Description: transmembrane protein 196, transcript variant 1 (from RefSeq NM_152774.3)
Gencode Transcript: ENST00000405764.7_9
Gencode Gene: ENSG00000173452.15_13
Transcript (Including UTRs)
   Position: hg19 chr7:19,758,939-19,813,016 Size: 54,078 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr7:19,761,698-19,812,319 Size: 50,622 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:19,758,939-19,813,016)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM196_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 196;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=BX648384; Type=Frameshift; Positions=72;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.64 RPKM in Brain - Hypothalamus
Total median expression: 22.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -264.70697-0.380 Picture PostScript Text
3' UTR -593.402759-0.215 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q5HYL7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BX648384 - Homo sapiens mRNA; cDNA DKFZp686H19205 (from clone DKFZp686H19205).
BX647256 - Homo sapiens mRNA; cDNA DKFZp686K0753 (from clone DKFZp686K0753).
BC030104 - Homo sapiens transmembrane protein 196, mRNA (cDNA clone MGC:42090 IMAGE:4797383), complete cds.
JD066000 - Sequence 47024 from Patent EP1572962.
JD564996 - Sequence 546020 from Patent EP1572962.
JD203035 - Sequence 184059 from Patent EP1572962.
KJ904080 - Synthetic construct Homo sapiens clone ccsbBroadEn_13474 TMEM196 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000405764.1, ENST00000405764.2, ENST00000405764.3, ENST00000405764.4, ENST00000405764.5, ENST00000405764.6, NM_152774, Q5HYL7, Q8N6I6, TM196_HUMAN, uc319dea.1, uc319dea.2
UCSC ID: ENST00000405764.7_9
RefSeq Accession: NM_001366626.1
Protein: Q5HYL7 (aka TM196_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.